Front-line High-Dose Chemotherapy with Rituximab Showed Excellent Long-Term Survival in Adults with Aggressive Large B-Cell Lymphoma: Final Results of.

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Front-line High-Dose Chemotherapy with Rituximab Showed Excellent Long-Term Survival in Adults with Aggressive Large B-Cell Lymphoma: Final Results of a Phase II GOELAMS Study Marie-Sarah Dilhuydy, Thierry Lamy, Charles Foussard, Remy Gressin, Philippe Casassus, Eric Deconninck, Christine Le Maignan, Diane Damotte, Noel Milpied Biology of Blood and Marrow Transplantation Volume 16, Issue 5, Pages 672-677 (May 2010) DOI: 10.1016/j.bbmt.2009.12.530 Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Flowchart of patients included in the GOELAMS 074 study. CEEP, cyclophosphamide, epirubicin, vindesine, prednisone; HDT, high-dose therapy; BEAM, carmustine, etoposide, cytarabine, melphalan. Biology of Blood and Marrow Transplantation 2010 16, 672-677DOI: (10.1016/j.bbmt.2009.12.530) Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 (A) In an intention-to-treat analysis, 5-year OS is 74%. Median survival is not reached. (B) In an intention-to-treat analysis, 5-year EFS is 55%. Biology of Blood and Marrow Transplantation 2010 16, 672-677DOI: (10.1016/j.bbmt.2009.12.530) Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 (A) Five-year OS according to aa-IPI is 82% for IH and 63% for high-risk patients (not statistically significant). (B) Five-year EFS according to aa-IPI is 56% for IH and 53% for high-risk patients (not statistically significant). Biology of Blood and Marrow Transplantation 2010 16, 672-677DOI: (10.1016/j.bbmt.2009.12.530) Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions