Covering the Cover Gastroenterology Andrew T. Chan, Christopher S. Williams  Gastroenterology  Volume 152, Issue 5, Pages 915-917 (April 2017) DOI: 10.1053/j.gastro.2017.02.035 Copyright © 2017 AGA Institute Terms and Conditions

Figure 1 Targeted in vivo images of flat sessile serrated adenoma in the proximal colon. (A) Endoscopic image with white light illumination shows limited visualization of sessile serrated adenoma. (B) Fluorescence image shows increased intensity and high contrast from sessile serrated adenoma compared with normal colonic mucosa. Gastroenterology 2017 152, 915-917DOI: (10.1053/j.gastro.2017.02.035) Copyright © 2017 AGA Institute Terms and Conditions

Figure 2 Representation of the proposed mechanism driving the PX20606-induced increase in FNS excretion and TICE. PX activates FXR in the intestine, leading to the production of FGF15/19, which, in turn, causes a shift in bile salt pool composition toward more hydrophilic bile salts. At the level of the enterocyte, excretion of cholesterol from the cell into the intestinal lumen is induced in a manner that depends largely on the activity of ABCG5/G8. Because the amount of ABCG5/G8 protein on the brush-border membrane remains unchanged upon PX treatment, the transport activity must be increased. Hydrophilic bile salts may facilitate increased export of cholesterol from enterocytes by ABCG5/G8. When re-uptake of exported cholesterol is blocked by addition of ezetimibe to the diet of PX-treated mice, this leads to even further increased cholesterol disposal from the body. Gastroenterology 2017 152, 915-917DOI: (10.1053/j.gastro.2017.02.035) Copyright © 2017 AGA Institute Terms and Conditions