Incidence of Adenovirus Infection in Hematopoietic Stem Cell Transplantation Recipients: Findings from the AdVance Study  Petr Sedláček, Toni Petterson,

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Presentation transcript:

Incidence of Adenovirus Infection in Hematopoietic Stem Cell Transplantation Recipients: Findings from the AdVance Study  Petr Sedláček, Toni Petterson, Marie Robin, Ponni Sivaprakasam, Enrikas Vainorius, Tom Brundage, Aastha Chandak, Essy Mozaffari, Garrett Nichols, Sebastian Voigt  Biology of Blood and Marrow Transplantation  Volume 25, Issue 4, Pages 810-818 (April 2019) DOI: 10.1016/j.bbmt.2018.12.753 Copyright © 2018 American Society for Blood and Marrow Transplantation Terms and Conditions

Biology of Blood and Marrow Transplantation 2019 25, 810-818DOI: (10 Biology of Blood and Marrow Transplantation 2019 25, 810-818DOI: (10.1016/j.bbmt.2018.12.753) Copyright © 2018 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure1 Incidence of AdV infection in allo-HCT recipients. *In any assay of blood, stool, urine or respiratory secretions within 6 months of transplantation. Note that incidence in pediatric and adult patients should not be compared directly. Biology of Blood and Marrow Transplantation 2019 25, 810-818DOI: (10.1016/j.bbmt.2018.12.753) Copyright © 2018 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure2 Time to first detection of AdV viremia with ≥1000copies/mL following allo-HCT. Biology of Blood and Marrow Transplantation 2019 25, 810-818DOI: (10.1016/j.bbmt.2018.12.753) Copyright © 2018 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure3 Prognostic factors for the development of AdV viremia ≥1000copies/mL within 6 months of allo-HCT in pediatric patients. Biology of Blood and Marrow Transplantation 2019 25, 810-818DOI: (10.1016/j.bbmt.2018.12.753) Copyright © 2018 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure4 Prognostic factors for the development of AdV viremia ≥1000copies/mL within 6 months of allo-HCT in adult patients.No recipients with a haploidentical donor type or a nonmalignant immunocompetent underlying disease developed AdV viremia ≥1000 copies/mL. Mismatched donor type is any category other than fully aligned HLAs. Biology of Blood and Marrow Transplantation 2019 25, 810-818DOI: (10.1016/j.bbmt.2018.12.753) Copyright © 2018 American Society for Blood and Marrow Transplantation Terms and Conditions