Taia T. Wang, Jeffrey V. Ravetch Immunity

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Immune Complexes: Not Just an Innocent Bystander in Chronic Viral Infection Taia T. Wang, Jeffrey V. Ravetch Immunity Volume 42, Issue 2, Pages 213-215 (February 2015) DOI: 10.1016/j.immuni.2015.01.022 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Crosslinking of Activating FcγRs Is Required for IgG Effector Functions Such as ADCC (Left) Model for B cell depletion through administration of an anti-CD20 mAb. Fc domains of anti-CD20 IgG bound to B cells crosslink activating FcγRs on the effector cell, resulting in cytotoxicity. (Right) Model for blocking of FcγRs in chronic LCMV infection. IC formed in LCMV could block activating FcγRs, while not causing substantial receptor crosslinking, thus blocking IgG-mediated effector functions such as ADCC. Immunity 2015 42, 213-215DOI: (10.1016/j.immuni.2015.01.022) Copyright © 2015 Elsevier Inc. Terms and Conditions