This Month in Gastroenterology Jan Tack, John M. Carethers  Gastroenterology  Volume 134, Issue 1, Pages 1-4 (January 2008) DOI: 10.1053/j.gastro.2007.11.047 Copyright © 2008 AGA Institute Terms and Conditions

Figure 1 Relative risk (±95% CI) of colorectal cancer and regular intake of aspirin. Subdivision according to the duration of regular intake. Gastroenterology 2008 134, 1-4DOI: (10.1053/j.gastro.2007.11.047) Copyright © 2008 AGA Institute Terms and Conditions

Figure 2 Modeling of increase in overall health care costs (±95% confidence interval) at 5 years’ follow-up according to the presence of a hyperechogenic pattern on ultrasound (US) or elevated ALT levels (ALT) at baseline. Gastroenterology 2008 134, 1-4DOI: (10.1053/j.gastro.2007.11.047) Copyright © 2008 AGA Institute Terms and Conditions

Figure 3 IL-5 transgene-induced esophageal tissue remodeling. Histopathologic analysis was performed on the esophageal tissue sections of wild-type and an IL-5–transgenic mouse after Masson’s trichrome staining, as shown in (A–C). A representative photomicrograph of wild-type esophagus highlighting its basal layer thickness and lamina propria collagen level (A, original magnification, ×100). A representative photomicrograph of CD2–IL-5 transgenic mice demonstrates thickened basal layer and collagen accumulation in the lamina propria and muscularis mucosa (B, original magnification, ×100). Accumulated collagen in the lamina propria and elongated papillae is shown (C, original magnification, ×400). Morphometric analysis of basal layer thickness is shown in (D) and lamina propria collagen thickness is shown in (E). The data is expressed as mean ± SD, n = 12 mice. EP, epithelium; LP, lamina propria; LU, lumen; MS, muscularis mucosa. Gastroenterology 2008 134, 1-4DOI: (10.1053/j.gastro.2007.11.047) Copyright © 2008 AGA Institute Terms and Conditions

Figure 4 Hepatic Hepatic levels of hepcidin mRNA and prohepcidin. Expression levels of hepcidin mRNA (A) and prohepcidin (B) were measured by real-time RT-PCR and ELISA, respectively. The relative quantities of hepcidin mRNA in the liver were normalized to β-actin mRNA. The relative protein levels of prohepcidin were normalized by protein concentrations and expressed as ng/mg protein. *P < .05 (8 months) and **P < .01 (14 months) versus the same-age nontransgenic mice (TgM). The numbers in parentheses represent the number of animals examined in each group. Gastroenterology 2008 134, 1-4DOI: (10.1053/j.gastro.2007.11.047) Copyright © 2008 AGA Institute Terms and Conditions