Volume 119, Issue 4, Pages (October 2000)

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Volume 119, Issue 4, Pages 943-948 (October 2000) The effects of intestinal infusion of long-chain fatty acids on food intake in humans Stephen J. French, Cathryn A. Conlon, Sandra T. Mutuma, Myrtha Arnold, Nick W. Read, Gert Meijer, John Francis Gastroenterology Volume 119, Issue 4, Pages 943-948 (October 2000) DOI: 10.1053/gast.2000.18139 Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 1 Test meal intake after upper intestinal infusion of saline and lipid infusions. Values are expressed as mean ± SEM. *P < 0.05 compared with saline infusion. Gastroenterology 2000 119, 943-948DOI: (10.1053/gast.2000.18139) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 2 The effect of upper intestinal infusions (●, control; ■, Intralipid; ▴, linoleic; ▾, oleic; ♦, stearic/oleic) on visual analogue scale ratings of (A) hunger and (B) fullness. Values are expressed as mean ± SEM. Gastroenterology 2000 119, 943-948DOI: (10.1053/gast.2000.18139) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 3 The effect of upper intestinal infusions (●, control; ■, Intralipid; ▴, linoleic; ▾, oleic; ♦, stearic/oleic) on plasma triglyceride concentration. Values are expressed as mean ± SEM. Gastroenterology 2000 119, 943-948DOI: (10.1053/gast.2000.18139) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 4 Fatty acid–induced CCK secretion. (A) Time course of CCK responses to fatty acid infusion. Peak CCK levels were reached within 20 minutes after the commencement of infusion for all lipid infusions (●, control; ■, intralipid; ▴, linoleic; ▾, oleic; ♦, stearic/oleic). CCK response after Intralipid infusion was significantly different from saline at all time points from 20 minutes onward and from all other fatty acid infusion conditions from 20 minutes onward apart from time 30. *P < 0.05 vs. control and modified oil emulsions; †P < 0.05 vs. control. (B) Area under plasma CCK curve during control and lipid infusions. Total CCK response after Intralipid infusion was significantly greater than both control and all modified oil emulsions, total CCK response after modified oil emulsions was significantly greater than control infusion, and there were no differences in CCK response between modified oil emulsion infusions. *P < 0.05 vs. control and modified oil emulsions; †P < 0.05 vs. control. Values are expressed as mean ± SEM. Gastroenterology 2000 119, 943-948DOI: (10.1053/gast.2000.18139) Copyright © 2000 American Gastroenterological Association Terms and Conditions