Volume 139, Issue 3, Pages 828-835.e3 (September 2010) Keratin Variants Predispose to Acute Liver Failure and Adverse Outcome: Race and Ethnic Associations  Pavel Strnad, Qin Zhou, Shinichiro Hanada, Laura C. Lazzeroni, Bi Hui Zhong, Phillip So, Timothy J. Davern, William M. Lee, M. Bishr Omary  Gastroenterology  Volume 139, Issue 3, Pages 828-835.e3 (September 2010) DOI: 10.1053/j.gastro.2010.06.007 Copyright © 2010 AGA Institute Terms and Conditions

Supplementary Figure 1 Conservation of the novel K8/K18 variants among species. (A−E) Sequences surrounding the novel K8/K18 variants detected in acute liver failure patients. Dots highlight conserved amino acids, while dashes indicate gaps which are included to optimize sequence alignment. The figure was assembled using the following sequences: K8: NM_002273.2 (Homo sapiens), NM_199370.1 (Rattus norwegicus), NM_031170.2 (Mus musculus), NM_001087056.1 (Xenopus laevis), NM_200080.2 (Danio rerio); K18: NM_000224.2 (Homo sapiens), NM_053976.1 (Rattus norwegicus), NM_010664.1 (Mus musculus), NM_001087341.1 (Xenopus laevis), NM_178437.2 (Danio rerio). There is limited conservation of the involved residues when compared among the type-I and type-II keratins (not shown). Gastroenterology 2010 139, 828-835.e3DOI: (10.1053/j.gastro.2010.06.007) Copyright © 2010 AGA Institute Terms and Conditions