Rifampin (INN Rifampicin)

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Presentation transcript:

Rifampin (INN Rifampicin) Paul Howard, BMedSci, MRCP, Robert Twycross, DM, FRCP, Graham Grove, FRACP, Sarah Charlesworth, BPharm (Hons) DipClinPharm, MRPharmS, Mary Mihalyo, BS, PharmD, RPh, Andrew Wilcock, DM, FRCP Journal of Pain and Symptom Management Volume 50, Issue 6, Pages 891-895 (December 2015) DOI: 10.1016/j.jpainsymman.2015.09.004 Copyright © 2015 Terms and Conditions

Fig An approach to the treatment of cholestatic pruritus used in some centers aspecialist guidelines recommend cholestyramine for incomplete biliary obstruction, e.g., PBC.18,19,21 Note. Because cholestyramine binds bile salts within the gut, it is ineffective in complete biliary obstruction. It is also unpalatable, and needs to be administered separately from other drugs. balthough experience with sertraline is limited (n=12 cross-over study in non-cancer cholestasis, mostly PBC),22 its tolerability, familiarity and limited interactions compared with rifampin generally means that it is tried first. cbenefit reported with androgens remains anecdotal.23,24 dalthough benefit confirmed in two small RCTs (n=36, mostly PBC), naltrexone (an opioid antagonist) is contra-indicated in patients needing opioid analgesia.25,26 Journal of Pain and Symptom Management 2015 50, 891-895DOI: (10.1016/j.jpainsymman.2015.09.004) Copyright © 2015 Terms and Conditions