Michael Camilleri Clinical Gastroenterology and Hepatology

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Presentation transcript:

Chronic diarrhea: a review on pathophysiology and management for the clinical gastroenterologist Michael Camilleri Clinical Gastroenterology and Hepatology Volume 2, Issue 3, Pages 198-206 (March 2004) DOI: 10.1016/S1542-3565(04)00003-5

Figure 1 Carcinoid diarrhea causing rapid colonic transit of isotope. Note that in 2 hours, isotope has moved from cecum to rectum. (Reprinted with permission from von der Ohe et al.23 Copyright© 1993 Massachusetts Medical Society. All rights reserved.) Inset above: Note the H&E appearance of carcinoid tumors with sheets of well-defined cells. Inset below: Note the chromogranin-positive cells demonstrating the presence of secretory granules within the carcinoid tumor cells. Clinical Gastroenterology and Hepatology 2004 2, 198-206DOI: (10.1016/S1542-3565(04)00003-5)

Figure 2 Initial management algorithm based on features accompanying diarrhea. p.r., per rectum; IBS, irritable bowel syndrome. Clinical Gastroenterology and Hepatology 2004 2, 198-206DOI: (10.1016/S1542-3565(04)00003-5)

Figure 3 Algorithm for management when abnormal findings are identified on limited screen for organic disease. Hb, hemoglobin; Alb, albumin; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; OSM, osmolality. Clinical Gastroenterology and Hepatology 2004 2, 198-206DOI: (10.1016/S1542-3565(04)00003-5)