Different weights (size of the circles) and ... Different weights (size of the circles) and interrelationship of risk factors in the pathogenesis of OA at different sites. Synovial inflammation is frequently present, while chondrocyte phenotype modification (hypertrophy with enhanced production of inflammatory molecules) is a constant feature. In knee OA, BMI acts on mechanical stress and via adipokines, while in hand OA it presumably acts only via adipokines. Coll2: collagen type 2; AGC: aggrecan. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) 2018. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.comThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Rheumatology (Oxford), Volume 58, Issue 5, 09 October 2018, Pages 743–745, https://doi.org/10.1093/rheumatology/key300 The content of this slide may be subject to copyright: please see the slide notes for details.