Bryan Krock, Nicolas Skuli, M. Celeste Simon Cell Metabolism

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Presentation transcript:

The Tumor Suppressor LKB1 Emerges as a Critical Factor in Hematopoietic Stem Cell Biology Bryan Krock, Nicolas Skuli, M. Celeste Simon Cell Metabolism Volume 13, Issue 1, Pages 8-10 (January 2011) DOI: 10.1016/j.cmet.2010.12.015 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 Role of LKB1 in Hematopoietic Stem Cells LKB1 promotes HSC quiescence and maintenance through regulating proliferation, metabolism, and cell survival in an AMPK-, mTORC1-, and FoxO-independent mechanism. The LKB1 target that mediates HSC function is unknown and could be one of the 14 known AMPK-related kinases. AMPK, mTORC1, and FoxO are regulated by LKB1 in HSCs but do not contribute to HSC quiescence. Cell Metabolism 2011 13, 8-10DOI: (10.1016/j.cmet.2010.12.015) Copyright © 2011 Elsevier Inc. Terms and Conditions