The Impact of Deep Versus Moderate Hypothermia on Postoperative Kidney Function After Elective Aortic Hemiarch Repair George J. Arnaoutakis, MD, Prashanth.

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The Impact of Deep Versus Moderate Hypothermia on Postoperative Kidney Function After Elective Aortic Hemiarch Repair George J. Arnaoutakis, MD, Prashanth Vallabhajosyula, MD, Joseph E. Bavaria, MD, Ibrahim Sultan, MD, Mary Siki, BS, Suveeksha Naidu, BA, Rita K. Milewski, MD, PhD, Matthew L. Williams, MD, W. Clark Hargrove, MD, Nimesh D. Desai, MD, PhD, Wilson Y. Szeto, MD The Annals of Thoracic Surgery Volume 102, Issue 4, Pages 1313-1321 (October 2016) DOI: 10.1016/j.athoracsur.2016.04.007 Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Detailed breakdown of the Risk, Injury, Failure, Loss, End-Stage (RIFLE) criteria as defined according to the Acute Dialysis Quality Initiative workshop (ADQI). The RIFLE system also includes differentiation between increasing severity of kidney injury (RIFLE Risk, Injury, or Failure) and 2 outcome categories L (loss, temporary dialysis) and E (end stage, permanent dialysis). Glomerular filtration rate (GFR) criteria (based on serum creatinine levels) and urine output criteria can be used to assign patients to appropriate RIFLE class. (UOP = urine output.) The Annals of Thoracic Surgery 2016 102, 1313-1321DOI: (10.1016/j.athoracsur.2016.04.007) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 In-hospital mortality according to increasing severity of Risk, Injury, Failure, Loss, End-Stage (RIFLE) classification. (RIFLE-0 = No AKI; RIFLE-R = RISK; RIFLE-I = Injury.) The Annals of Thoracic Surgery 2016 102, 1313-1321DOI: (10.1016/j.athoracsur.2016.04.007) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 (A) Comparison of in-hospital mortality according to whether patients met Kidney Disease: Improving Global Outcomes (KDIGO) criteria for acute kidney injury (AKI); p = 0.01 by χ2 analysis. (B) Comparison of proportion of patients discharged directly to home according to whether patients met KDIGO criteria for AKI; p = 0.01 by χ2 analysis. (C) Comparison of the hospital length of stay according to whether patients met KDIGO criteria for AKI; p = 0.01 by rank-sum analysis. The Annals of Thoracic Surgery 2016 102, 1313-1321DOI: (10.1016/j.athoracsur.2016.04.007) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Odds ratio plot of variables included in the risk-adjusted logistic regression model for acute kidney injury (AKI). Diamonds represent actual odds ratio values and gray bars denote 95% confidence interval (CI). C-index for the model was 0.72, and asterisks denote significant predictors. (CP = cardiopulmonary bypass; CPB = cardiopulmonary bypass; EF = ejection fraction; GFR = glomerular filtration rate; PAD = peripheral arterial disease; RCP = retrograde cerebral perfusion.) The Annals of Thoracic Surgery 2016 102, 1313-1321DOI: (10.1016/j.athoracsur.2016.04.007) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions