A 79-Year-Old Woman With Bilateral Cavitating Lung Nodules

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Presentation transcript:

A 79-Year-Old Woman With Bilateral Cavitating Lung Nodules Karan Madan, MD, DM, Suvendu Purkait, MD, Sudheer Arava, MD, Ashu S. Bhalla, MD, Rakesh Kumar, MD, Randeep Guleria, MD, DM CHEST Volume 145, Issue 6, Pages 1419-1424 (June 2014) DOI: 10.1378/chest.13-2081 Copyright © 2014 The American College of Chest Physicians Terms and Conditions

Figure 1 A, Chest radiograph demonstrating multiple bilateral variable-sized pulmonary nodules, some of which show central cavitation (arrows). B-C, CT scan of the thorax showing multiple variable-sized, randomly distributed pulmonary nodules predominantly in the lower lobes. Many show central cavitation. There is no halo surrounding the nodules. CHEST 2014 145, 1419-1424DOI: (10.1378/chest.13-2081) Copyright © 2014 The American College of Chest Physicians Terms and Conditions

Figure 2 Fluorodeoxyglucose (FDG)-PET/CT imaging findings demonstrating multiple FDG avid cavitating pulmonary nodules. The corresponding CT scan images are also shown. CHEST 2014 145, 1419-1424DOI: (10.1378/chest.13-2081) Copyright © 2014 The American College of Chest Physicians Terms and Conditions

Figure 3 Histopathologic examination findings from the CT scan-guided lung biopsy. A, Diffuse infiltration of lung parenchyma by medium- to large-sized atypical lymphoid cells with destruction of alveolar architecture (hematoxylin & eosin, magnification × 400). B, Membranous/cytoplasmic immunopositivity for CD20 (magnification × 400). C, Immunonegativity for CD3 (magnification × 400). D, Nuclear immunopositivity for MUM1 (× 400). CHEST 2014 145, 1419-1424DOI: (10.1378/chest.13-2081) Copyright © 2014 The American College of Chest Physicians Terms and Conditions