Do Complex Mutations of the Epidermal Growth Factor Receptor Gene Reflect Intratumoral Heterogeneity? Akito Hata, MD, Shiro Fujita, MD, PhD, Reiko Kaji,

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Presentation transcript:

Do Complex Mutations of the Epidermal Growth Factor Receptor Gene Reflect Intratumoral Heterogeneity? Akito Hata, MD, Shiro Fujita, MD, PhD, Reiko Kaji, MD, Nobuyuki Katakami, MD, PhD, Yukihiro Imai, MD, PhD Journal of Thoracic Oncology Volume 6, Issue 6, Pages 1144-1146 (June 2011) DOI: 10.1097/JTO.0b013e31821b1194 Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Computed tomography-guided lung biopsy performed on the tumor harboring complex mutations with G719S and L858R. Journal of Thoracic Oncology 2011 6, 1144-1146DOI: (10.1097/JTO.0b013e31821b1194) Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 The magnetic resonance image shows findings of leptomeningeal metastases (arrow heads). Journal of Thoracic Oncology 2011 6, 1144-1146DOI: (10.1097/JTO.0b013e31821b1194) Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 3 Right pleural effusion containing adenocarcinoma cells harboring complex mutations with Del-19 and L858R, and pleural disseminations are shown. Journal of Thoracic Oncology 2011 6, 1144-1146DOI: (10.1097/JTO.0b013e31821b1194) Copyright © 2011 International Association for the Study of Lung Cancer Terms and Conditions