Evaluation of Explanted CorMatrix Intracardiac Patches in Children With Congenital Heart Disease Jennifer S. Nelson, MD, MS, Amer Heider, MD, Ming-Sing.

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Evaluation of Explanted CorMatrix Intracardiac Patches in Children With Congenital Heart Disease Jennifer S. Nelson, MD, MS, Amer Heider, MD, Ming-Sing Si, MD, Richard G. Ohye, MD The Annals of Thoracic Surgery Volume 102, Issue 4, Pages 1329-1335 (October 2016) DOI: 10.1016/j.athoracsur.2016.03.086 Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 (A) Hemi-Fontan patch baffle location within the right atrium. The patch separates the superior vena caval/pulmonary artery junction from the body of the right atrium. (B) Patch removal at Fontan operation. (Reprinted with permission from Elsevier from Bove EL, Mosca RS. Surgical repair of the hypoplastic left heart syndrome. Prog Pediatr Cardiol 1996;5:23–35.) The Annals of Thoracic Surgery 2016 102, 1329-1335DOI: (10.1016/j.athoracsur.2016.03.086) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 (A) Control; collagen and ghost outlines of nuclei are shown. (Hematoxylin and eosin; ×10.) (B) Control; connective tissue with collagen stained blue. (Trichrome; ×10.) The Annals of Thoracic Surgery 2016 102, 1329-1335DOI: (10.1016/j.athoracsur.2016.03.086) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 (A) Low-power magnification with hematoxylin and eosin (H&E) stain showing section of the CorMatrix patch with a band of chronic inflammation and aggregates of histiocytes. (B) High-power magnification with H&E stain showing a section of the CorMatrix patch. This photomicrograph highlights the foreign body multinucleated giant cell reaction. The Annals of Thoracic Surgery 2016 102, 1329-1335DOI: (10.1016/j.athoracsur.2016.03.086) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Trichrome stain at low-power magnification highlighting the acellular CorMatrix and the associated fibrosis. The Annals of Thoracic Surgery 2016 102, 1329-1335DOI: (10.1016/j.athoracsur.2016.03.086) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 5 Movat pentachrome stain at low-power magnification with disorganized elastic fibers (stained black). The Annals of Thoracic Surgery 2016 102, 1329-1335DOI: (10.1016/j.athoracsur.2016.03.086) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 6 (A) Low-power and (B) high-power hematoxylin and eosin stain showing membranous fibroconnective tissue with mild chronic inflammation and dystrophic calcification (arrow). The Annals of Thoracic Surgery 2016 102, 1329-1335DOI: (10.1016/j.athoracsur.2016.03.086) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions