Modified antigenic reactivity of anti-phospholipase A2 IgG antibodies in patients allergic to bee venom: Conversion with immunotherapy and relation to.

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Presentation transcript:

Modified antigenic reactivity of anti-phospholipase A2 IgG antibodies in patients allergic to bee venom: Conversion with immunotherapy and relation to subclass expression Alain Michils, MD, PhDa, Michel Mairesse, MDb, Claire Ledent, MDb, Béatrice Gossart, BSc, Sandra Baldassarre, MDa, Jean Duchateau, MD, PhDc Journal of Allergy and Clinical Immunology Volume 102, Issue 1, Pages 118-126 (July 1998) DOI: 10.1016/S0091-6749(98)70062-4 Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 1 Frequency histograms of specific IgG titers after natural logarithmic transformation for allergic (preimmunotherapy), VIT, and healthy control populations. Journal of Allergy and Clinical Immunology 1998 102, 118-126DOI: (10.1016/S0091-6749(98)70062-4) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 2 Distribution of percentage inhibitions of allergic pooled IgG binding to PLA2 by individual sera from allergic (preimmunotherapy), VIT, and healthy control groups. Journal of Allergy and Clinical Immunology 1998 102, 118-126DOI: (10.1016/S0091-6749(98)70062-4) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 3 Distribution of percentage inhibitions of VIT-pooled IgG binding to PLA2 by individual sera from allergic (preimmunotherapy), VIT, and healthy control groups. Journal of Allergy and Clinical Immunology 1998 102, 118-126DOI: (10.1016/S0091-6749(98)70062-4) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 4 Evolution of mean inhibition capacity of sera from allergic patients during VIT (binding inhibition of allergic [preimmunotherapy] and VIT-pooled IgG fraction). Journal of Allergy and Clinical Immunology 1998 102, 118-126DOI: (10.1016/S0091-6749(98)70062-4) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 5 Inhibition of binding of allergic pooled IgG1 (A) and IgG4 (B) by pooled sera from allergic patients, healthy individuals, and patients receiving VIT for 15 days and 2 years. Journal of Allergy and Clinical Immunology 1998 102, 118-126DOI: (10.1016/S0091-6749(98)70062-4) Copyright © 1998 Mosby, Inc. Terms and Conditions