Matching Cell Type to Function in Cortical Circuits

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Presentation transcript:

Matching Cell Type to Function in Cortical Circuits Luc Estebanez, Jens Kremkow, James F.A. Poulet Neuron Volume 87, Issue 2, Pages 249-251 (July 2015) DOI: 10.1016/j.neuron.2015.06.039 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Cell-Type-Specific Functional Response Tuning in dmPFC to Task-Related Events in a GO/NO-GO Sensory Discrimination Behavior (A) Left: cartoon mouse brain with coronal slice of recording site highlighted in yellow. Right: cartoon of the slice showing the dorso-medial prefrontal cortex (gray area). Highlighted yellow section shows imaging site, the right prelimbic cortex. (B) GO/NO-GO behavioral task. Following a visual cue, the mouse was exposed to a sound with either a target or a non-target frequency. Licking in a 1.5-s response window after the target tone was rewarded by water, while licking following the non-target tone was punished with an airpuff. If the mouse failed to lick, there was no reward or punishment. (C) Schematic showing the similarity of the response tuning of neurons of the same subtype. Note the high correlation among interneuron subtypes versus the difference of activity between PYR neurons. (D) Schematic showing functional response tuning of calcium signal in SST interneurons to sensory, motor, and motivational features of a GO/NO-GO behavior. (E) Same as (D) but for PV interneurons. (F) Same as (D) but for VIP interneurons. Neuron 2015 87, 249-251DOI: (10.1016/j.neuron.2015.06.039) Copyright © 2015 Elsevier Inc. Terms and Conditions