Cortical Necrosis American Journal of Kidney Diseases

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Presentation transcript:

Cortical Necrosis American Journal of Kidney Diseases Agnes Fogo, MD American Journal of Kidney Diseases Volume 41, Issue 1, Pages E27-E28 (January 2003) DOI: 10.1053/S0272-6386(13)90050-0 Copyright © 2003 National Kidney Foundation, Inc. Terms and Conditions

Fig 1 Cortical necrosis is distinguished from acute tubular necrosis in that glomeruli as well as tubules show frank necrosis. It most often has a vascular occlusive etiology. Coagulative necrosis is widespread in this transplant biopsy and is manifest by small, pyknotic nuclei and ghost-like outlines of cells, characteristic of coagulative necrosis (periodic acid Schiff, ×400). American Journal of Kidney Diseases 2003 41, E27-E28DOI: (10.1053/S0272-6386(13)90050-0) Copyright © 2003 National Kidney Foundation, Inc. Terms and Conditions

Fig 2 Cortical necrosis with tubular necrosis and glomerular necrosis. The glomerular basement membrane is still visualized, but there are no viable nuclei in the glomerulus, and surrounding tubules show frank necrosis, as do the adjacent arterioles (Jones' silver stain, ×400). American Journal of Kidney Diseases 2003 41, E27-E28DOI: (10.1053/S0272-6386(13)90050-0) Copyright © 2003 National Kidney Foundation, Inc. Terms and Conditions

Fig 3 Cortical necrosis with widespread frank tubular necrosis with no nuclei discernible in tubules and ghost-like outlines of cells, characteristic of coagulative necrosis (periodic acid Schiff, ×200). American Journal of Kidney Diseases 2003 41, E27-E28DOI: (10.1053/S0272-6386(13)90050-0) Copyright © 2003 National Kidney Foundation, Inc. Terms and Conditions

Fig 4 Cortical necrosis with widespread frank tubular necrosis with no nuclei discernible in most tubules and ghost-like outlines of cells, characteristic of coagulative necrosis. There are also pyknotic nuclei and karryorhexis, characteristic of coagulative necrosis (periodic acid Schiff, ×400). American Journal of Kidney Diseases 2003 41, E27-E28DOI: (10.1053/S0272-6386(13)90050-0) Copyright © 2003 National Kidney Foundation, Inc. Terms and Conditions