Free radical reaction products and antioxidant capacity in arterial plasma during coronary artery bypass grafting Hannu J. Toivonen, MD, PhDa, Markku.

Slides:

Advertisements

Similar presentations

Regional generation of free oxygen radicals during cardiopulmonary bypass in children Eero J. Pesonen, MDa, Reijo Korpela, MDa, Kaija Peltola, MDa, Mauri.

Advertisements

Influence of normothermic systemic perfusion during coronary artery bypass operations: A randomized prospective study Inderpaul Birdi, FRCS, Idris Regragui,

Reduced complement activation and improved postoperative performance after cardiopulmonary bypass with heparin-coated circuits Piet G.M. Jansen, MD,

Regional generation of free oxygen radicals during cardiopulmonary bypass in children Eero J. Pesonen, MDa, Reijo Korpela, MDa, Kaija Peltola, MDa, Mauri.

Effects of diltiazem on perioperative ischemia, arrhythmias, and myocardial function in patients undergoing elective coronary bypass grafting Rainald.

Heparin-coated cardiopulmonary bypass equipment. II

Platelet-rich plasmapheresis in cardiac surgery: A meta-analysis of the effect on transfusion requirements F.D. Rubens, MDa, D. Fergusson, MHAb, P.S.

Yuji Hiramatsu, MDa, Nicolas Gikakis, BSEa, Harry L

Juan C. Araque, MD, Kevin L. Greason, MD, Zhuo Li, MS, Courtney N

Coronary artery bypass grafting with the descending branch of thelateral femoral circumflex artery used as an arterial conduit: Is arteriographicevaluation.

Optimal flow rates for integrated cardioplegia

Studies of hypoxemic/reoxygenation injury: With aortic clamping

P. W. Boonstra, MD, PhD, Y. J. Gu, MD, PhD, C. Akkerman, BSc, J

Is the heart a source for elevated circulating endothelin levels during aorta—coronary artery bypass grafting surgery in human beings? David Hasdai,

Right internal thoracic artery or saphenous vein grafting

Relationship of the proinflammatory cytokines to myocardial ischemia and dysfunction after uncomplicated coronary revascularization Hani A. Hennein,

Penetration of intravenous antibiotics from the lung into the pleural space after pulmonary resection* T. Sakuma, MD, H. Kubo, MD, T. Tanita, MD, K.

Lower graft patency after off-pump than on-pump coronary artery bypass grafting: An updated meta-analysis of randomized trials Hisato Takagi, MD, PhD,

Steven R. Gundry, MD, Matthew A. Romano, MD, O

How safe is the port access technique in minimally invasive coronary artery bypass grafting? Selami Dogan, MD, Kai Graubitz, MD, Tayfun Aybek, MD, Mohammad.

Multilevel data analysis: What? Why? How?

Intracellular free calcium accumulation in ferret vascular smooth muscle during crystalloid and blood cardioplegic infusions Motohisa Tofukuji, MD, PhDa,

Harold L. Lazar, MD The Journal of Thoracic and Cardiovascular Surgery

Descending branch of lateral femoral circumflex artery as a free graft for myocardial revascularization: A case report Takahiko O. Tatsumi, MD, PhDa,

Studies of hypoxemic/reoxygenation injury with aortic clamping

Comparison of perioperative myocardial protection with nifedipine versus nifedipine and metoprolol in patients undergoing elective coronary artery bypass.

Postoperative diaphragmatic hernia after use of the right gastroepiploic artery for coronary artery bypass grafting Miralem Pasic, MD, PhD, Thierry Carrel,

The effects of heparin and extracorporeal circulation on platelet counts and platelet microaggregation during cardiopulmonary bypass Elijah W. Muriithi,

Biocompatibility of heparin-coated extracorporeal bypass circuits: A randomized, masked clinical trial Derek D. Muehrcke, MDa, Patrick M. McCarthy, MDa,

Effect of esophageal distention on pressure and electromyographic activity of the pharyngoesophageal sphincter, with identification of the esophagopharyngeal.

Surgical economics: MACRA, MIPS, and bundles—Lessons learned in the first 3 years of a coronary artery bypass grafting alternative payment model Daniel.

Editorial: The core of leadership

Coagulation, fibrinolysis, and cell activation in patients and shed mediastinal blood during coronary artery bypass grafting with a new heparin-coated.

Support Your Specialty

T. Carrel, MD, M. Pasic, MD, U. Niederhäuser, MD, M. Turina, MD

Platelet-leukocyte activation and modulation of adhesion receptors in pediatric patients with congenital heart disease undergoing cardiopulmonary bypass

Regional generation of free oxygen radicals during cardiopulmonary bypass in children Eero J. Pesonen, MDa, Reijo Korpela, MDa, Kaija Peltola, MDa, Mauri.

Endothelin-1 during and after cardiopulmonary bypass: Association to graft sensitivity and postoperative recovery Brian R. Bond, PhD, B.Hugh Dorman,

Complement and granulocyte activation in two different types of heparinized extracorporeal circuits Eivind Øvrum, MDa, Tom Eirik Mollnes, MD, PhDb, Erik.

Pulmonary metabolism of endothelin 1 during on-pump and beating heart coronary artery bypass operations Patrick Mathieu, MDa, Jocelyn Dupuis, MD, PhDb,

Reversal of refractory hypotension with single-dose methylene blue after coronary artery bypass surgery P. Yiu, FRCSa, J. Robin, MRCPb, C.W. Pattison,

Release of the cerebral protein S-100 into blood after reperfusion during cardiac operations in infants: Is there a relation to oxygen radical–induced.

Hisato Takagi, MD, PhD, Takuya Umemoto, MD, PhD

Kai Ihnken, MD The Journal of Thoracic and Cardiovascular Surgery

Increase in size of the pulmonary autograft after the ross operation in children: Growth or dilation? Laszlo Solymar, MD, PhD, Göran Südow, MD, Daniel.

Insulin cardioplegia for elective coronary bypass surgery

Influence of experience and the surgical learning curve on long-term patient outcomes in cardiac surgery Bryan M. Burt, MD, Andrew W. ElBardissi, MD,

Difference in acetylcholine-induced nitric oxide release of arterial and venous grafts in patients after coronary bypass operations Hiroaki Nishioka,

Combined valve replacement and myocardial revascularization

Elspeth M. Brown, MRCP, Anthony P. Salmon, FRCP, Robert K. Lamb, FRCS

Cardiac cannulation, sodium and water balance, and ANF plasma levels

Aspirin resistance after coronary artery bypass grafting

Nitric oxide mediates fluid accumulation during cardiopulmonary bypass

Ralph S. Mosca, MD The Journal of Thoracic and Cardiovascular Surgery

Protection of the human heart with ischemic preconditioning during cardiac surgery: role of cardiopulmonary bypass Sudip Ghosh, MD, Manuel Galiñanes,

P.K. Spanos, MD, A.D. Bisbos, MD, I.I. Arditis, MD

Postbypass effects of delayed rewarming on cerebral blood flow velocities in infants after total circulatory arrest Rosendo A. Rodriguez, MD, PhDa (by.

Trends in Patient Characteristics and Outcomes of Coronary Artery Bypass Grafting in the 2000 to 2012 Medicare Population Christian McNeely, MD, Stephen.

Discussion The Journal of Thoracic and Cardiovascular Surgery

Natriuresis after cardiopulmonary bypass: Relationship to urodilatin, atrial natriuretic factor, antidiuretic hormone, and aldosterone Jens Sehested,

Myocardium is a major source of proinflammatory cytokines in patients undergoing cardiopulmonary bypass Song Wan, MDa, Jean-Marie DeSmet, MDa, Luc Barvais,

Minimally invasive direct coronary artery bypass, percutaneous transluminal coronary angioplasty, and stent placement for left main stenosis William.

Dumbor L. Ngaage, MD, FRCS (C-Th), Michael E. Cowen, FRCS

Masao Takahashi, MD, Shinichiro Yamamoto, MD, Shigeki Tabata, MD

Gary E. Hill, MD, FCCMa,b, Anselmo Alonso, MDc, John R

Comparing microvascular alterations during minimal extracorporeal circulation and conventional cardiopulmonary bypass in coronary artery bypass graft.

Y.John Gu, MD, PhD, Piet W. Boonstra, MD, PhD, Willem van Oeveren, PhD

Recombinant hirudin for extended aortic surgery in patients with heparin-induced thrombocytopenia Matthias Bauer, MD, Andreas Koster, MD, Miralem Pasic,

Commentary: Radial artery and bilateral mammary arteries in coronary artery bypass grafting: How much is too much? Derrick Y. Tam, MD, Stephen E. Fremes,

Hemostasis Alterations in Patients With Acute Aortic Dissection

Presentation transcript:

Free radical reaction products and antioxidant capacity in arterial plasma during coronary artery bypass grafting Hannu J. Toivonen, MD, PhDa, Markku Ahotupa, PhDb The Journal of Thoracic and Cardiovascular Surgery Volume 108, Issue 1, Pages 140-147 (July 1994) DOI: 10.5555/uri:pii:S0022522394702306 Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 1 Line graphs showing relative amount of fluorescent chromolipids inarterial plasma during different phases of CABG operation. Upper panel shows values after correction for hemodilution; lower panel shows actual measured plasma concentrations as percentage offirst data point (mean ± SEM of nine patients).Sample times: 1: before anesthesia induction; 2: 10 minutes after anesthesia induction; 3: 45 minutes after anesthesia induction; 4:before heparin (200 IU/kg); 5: 5 minutes after heparin; 6: 5 minutes from the start of extracorporeal circulation; 7: 5 minutes after administration of cardioplegic solution; 8: 45 minutes from the start of extracorporeal circulation (n = 7); 9: before aortic crossclamp removal; 10: 5 minutes after crossclamp removal; 11: 5 minutes after the termination of CPB; 12: afterprotamine administration; 13: 1 hour from the end of extracorporeal circulation.**Two × p < 0.01, difference from the first sample by analysis of variance followed by the Newman-Keuls test. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 140-147DOI: (10.5555/uri:pii:S0022522394702306) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 2 Line graphs showing the relative amount of diene conjugates in arterial plasma during different phases of CABG operation. Upper panel shows the values after correction for hemodilution; lower panel shows the actual measured plasma concentrations as percentage of first data point (mean ± SEM of nine patients). Sample time numbers refer to sample times of Fig. 1. **Two × p < 0.01, difference from the first sample by analysis of variance followed bythe Newman-Keuls test. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 140-147DOI: (10.5555/uri:pii:S0022522394702306) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 3 Line graphs showing relative amount of TBA reactive material(malondialdehyde) in arterial plasma during different phases of CABG operation. Upper panel shows the values after correction for the hemodilution; lower panel shows actual measured plasmaconcentrations as percentage of first data point (mean ± SEM of nine patients). Sample time numbers refer to sample times of Fig. 1. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 140-147DOI: (10.5555/uri:pii:S0022522394702306) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 4 Line graphs showing relative peroxyl radical binding capacity of arterial plasma during different phases of CABG operation. Upper panel shows the values after correction for the hemodilution; lower panel shows actual measured plasma concentrations as percentage of first data point (mean ± SEM of six patients). Sample time numbers refer to sample times of Fig. 1.*Two × p < 0.05;**2 × p < 0.01;difference from the first sample by analysis of variance followed by the Newman-Keuls test. The Journal of Thoracic and Cardiovascular Surgery 1994 108, 140-147DOI: (10.5555/uri:pii:S0022522394702306) Copyright © 1994 Mosby, Inc. Terms and Conditions