Vivian Barak, Ph. D. , Uriel Elchalal, M. D. , Michal Edelstein, M. D

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Presentation transcript:

Interleukin-18 levels correlate with severe ovarian hyperstimulation syndrome Vivian Barak, Ph.D., Uriel Elchalal, M.D., Michal Edelstein, M.D., Inna Kalickman, M.Sc., Aby Lewin, M.D., Yoram Abramov, M.D. Fertility and Sterility Volume 82, Issue 2, Pages 415-420 (August 2004) DOI: 10.1016/j.fertnstert.2004.03.024

FIGURE 1 Interleukin-18 (IL-18) levels in serum, peritoneal, and pleural fluids during the acute phase of OHSS (red colors) as compared to serum of IVF patients not developing OHSS (control group 2) and of healthy controls (control group 1) (green). Values are presented as mean ± SE. Asterisks indicate statistically significant differences, as compared with both control groups (P<.05). Barak. IL-18 correlates with severe OHSS. Fertil Steril 2004. Fertility and Sterility 2004 82, 415-420DOI: (10.1016/j.fertnstert.2004.03.024)

FIGURE 2 Serum interleukin-18 (IL-18) levels during the acute (red), convalescence (blue), and resolution (green) phases of OHSS. Values are presented as mean ± SE. Asterisks indicate statistically significant differences between the acute and both convalescence and resolution phases (P<.05). Barak. IL-18 correlates with severe OHSS. Fertil Steril 2004. Fertility and Sterility 2004 82, 415-420DOI: (10.1016/j.fertnstert.2004.03.024)

FIGURE 3 Serum interleukin 6 (IL-6) levels during the acute (red), convalescence (blue), and resolution (green) phases of OHSS. Values are presented as mean ± SE. Asterisks indicate statistically significant differences (P<.05). Barak. IL-18 correlates with severe OHSS. Fertil Steril 2004. Fertility and Sterility 2004 82, 415-420DOI: (10.1016/j.fertnstert.2004.03.024)

FIGURE 4 Changes in clinical parameters of OHSS during the acute, convalescence, and resolution phases. Hematocrit (HCT) = green line, white blood cell count (WBC × 103) = red line, serum estradiol levels (E2 × 103) = blue line. Barak. IL-18 correlates with severe OHSS. Fertil Steril 2004. Fertility and Sterility 2004 82, 415-420DOI: (10.1016/j.fertnstert.2004.03.024)