Serum free light chains in the differential diagnosis and prognosis of primary and secondary hypogammaglobulinemia Nicolò Compagno, MD, Francesco Cinetto,

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Serum free light chains in the differential diagnosis and prognosis of primary and secondary hypogammaglobulinemia Nicolò Compagno, MD, Francesco Cinetto, MD, Elisa Boscaro, PhD, Gianpietro Semenzato, MD, Carlo Agostini, MD Journal of Allergy and Clinical Immunology Volume 135, Issue 4, Pages 1075-1077.e6 (April 2015) DOI: 10.1016/j.jaci.2014.10.003 Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 sFLC levels in the differential diagnosis of hypogammaglobulinemia. The scatter plot shows sFLC levels for 45 patients with CVID and 44 patients with secondary antibody deficiency. Patients with CVID have an sFLC pattern different from that of patients with secondary hypogammaglobulinemia. sFLC patterns in patients with CVID are divided by dashed lines, as indicated. The square represents reference sFLC values. B-CLL, B-cell chronic lymphocytic leukemia. Journal of Allergy and Clinical Immunology 2015 135, 1075-1077.e6DOI: (10.1016/j.jaci.2014.10.003) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 B-cell subpopulations in the 4 sFLC subgroups and the whole CVID cohort (means and SEs). sFLC patterns seem to be able to differentiate between biological subgroups of the disease. Because only 1 patient presented with a κ+λ− pattern, we did not look for significant differences in B-cell subtypes for this group. *P < .05 and **P < .01. Journal of Allergy and Clinical Immunology 2015 135, 1075-1077.e6DOI: (10.1016/j.jaci.2014.10.003) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions