Zenith abdominal aortic aneurysm endovascular graft

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Presentation transcript:

Zenith abdominal aortic aneurysm endovascular graft Roy K. Greenberg, MD, Timothy A.M. Chuter, MD, Richard P. Cambria, MD, W. Charles Sternbergh, MD, Neal E. Fearnot, PhD Journal of Vascular Surgery Volume 48, Issue 1, Pages 1-9.e2 (July 2008) DOI: 10.1016/j.jvs.2008.02.051 Copyright © 2008 The Society for Vascular Surgery Terms and Conditions

Fig 1 Enrollment in the United States Zenith Multicenter Trial (ZMT). The pivotal portion of the trial included 80 surgical controls, 200 standard-risk endovascular patients, 100 high-risk endovascular patients, and 52 patients allocated to the roll-in arm. After pivotal enrollment was completed, continued access was provided through a separate study arm. At the conclusion of the 2-year follow-up, pivotal patients were given the opportunity to participate in an extended follow-up study carrying out annual assessments through 5 years. The various categories of the trial resulted in three fundamental patient groups: surgical controls, standard-risk endovascular, and high-risk endovascular. For analysis purposes, the roll-in, pivotal study, and continued access groups were combined into conglomerate standard- and high-risk endovascular groups, with a variable degree of follow-up. This flow chart shows enrollment and follow-up details. AAA, Abdominal aortic aneurysm. Journal of Vascular Surgery 2008 48, 1-9.e2DOI: (10.1016/j.jvs.2008.02.051) Copyright © 2008 The Society for Vascular Surgery Terms and Conditions

Fig 2 Kaplan-Meier graph shows mortality stratified by standard-risk (black line) and high-risk (red line) physiologic groups. Error bars represent 95% confidence intervals at each time point. Journal of Vascular Surgery 2008 48, 1-9.e2DOI: (10.1016/j.jvs.2008.02.051) Copyright © 2008 The Society for Vascular Surgery Terms and Conditions

Fig 3 The incidence of both new and persistent endoleaks by type and time of onset is shown for high-risk (red) and standard-risk (black) groups. The Kaplan-Meier plot shows the cumulative risk for a late endoleak of any type. Error bars represent 95% confidence intervals at each time point. No statistical differences were noted between the high- and standard-risk groups, although the numbers of patients at late follow-up time points were relatively small. Journal of Vascular Surgery 2008 48, 1-9.e2DOI: (10.1016/j.jvs.2008.02.051) Copyright © 2008 The Society for Vascular Surgery Terms and Conditions