Volume 375, Issue 9726, Pages (May 2010)

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Presentation transcript:

Volume 375, Issue 9726, Pages 1624-1633 (May 2010) Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial Prof Wendy S Atkin, PhD, Rob Edwards, PhD, Ines Kralj-Hans, PhD, Kate Wooldrage, MSc, Andrew R Hart, MD, Prof John MA Northover, MS, D Max Parkin, MD, Prof Jane Wardle, PhD, Prof Stephen W Duffy, MSc, Prof Jack Cuzick, PhD The Lancet Volume 375, Issue 9726, Pages 1624-1633 (May 2010) DOI: 10.1016/S0140-6736(10)60551-X Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 1 Trial profile *Prerandomisation events. The Lancet 2010 375, 1624-1633DOI: (10.1016/S0140-6736(10)60551-X) Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 2 Kaplan-Meier estimates of cumulative incidence and mortality Colorectal cancer incidence (A and B), distal cancer incidence (C and D), proximal cancer incidence (E and F), and colorectal cancer mortality (G and H). A, C, E, and G are intention-to-treat analyses. B, D, F, and H are per-protocol analyses. The Lancet 2010 375, 1624-1633DOI: (10.1016/S0140-6736(10)60551-X) Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 3 Smoothed yearly hazard rates for distal cancer (rectum and sigmoid colon) Curves are truncated at 10 years of follow-up because of incomplete ascertainment of cancers in the final calendar year of the study. The Lancet 2010 375, 1624-1633DOI: (10.1016/S0140-6736(10)60551-X) Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 4 Hazard ratios for colorectal cancer (all sites) in screened versus control groups by age group and sex Hazard ratios are adjusted for non-compliance with screening. The Lancet 2010 375, 1624-1633DOI: (10.1016/S0140-6736(10)60551-X) Copyright © 2010 Elsevier Ltd Terms and Conditions