Volume 57, Issue 2, Pages (October 2000)

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Volume 57, Issue 2, Pages 437-445 (October 2000) Apoptosis in parathyroid hyperplasia of patients with primary or secondary uremic hyperparathyroidism Ping Zhang, Patricia Duchambon, Jean Gogusev, Bernadette Nabarra, Emile Sarfati, Agnès Bourdeau, Tilman B. Drüeke, M.D. Kidney International Volume 57, Issue 2, Pages 437-445 (October 2000) DOI: 10.1046/j.1523-1755.2000.00863.x Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 1 Light microscopy evidence of apoptosis. Light microscopy examination of semithin sections of parathyroid tissue from a uremic patient with secondary (2°) hyperparathyroidism shows a large zone of parathyroid cells having predominantly a normal aspect with nuclei composed by sparse and dense clumps of chromatin, whereas few cells have nuclei exhibiting either mitotic (◂) or apoptotic (→) aspect (A; ×500). Greater magnification of one zone of this field shows various types of nuclei. The majority look morphologically normal whereas a few exhibit an aspect of mitosis (◂; B; ×1200). Another area of this zone shows several nuclei having a homogeneous, extremely dense chromatin characteristic of apoptosis (→; C; ×1200). Kidney International 2000 57, 437-445DOI: (10.1046/j.1523-1755.2000.00863.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 2 Apoptotic cells in parathyroid tissues revealed by TUNEL assay. Nuclear staining of positive cells is evidenced by distinct black spots, whereas negative cells have a diffuse purple aspect. (A) Typical feature of normal parathyroid tissue with one apoptotic cell per high power field. (B and C) Characteristic findings in patients with 2° hyperparathyroidism, respectively, containing one and five positive cells, respectively. (D) Representative feature of 1° hyperparathyroidism with three positive cells. (E and F) Negative (absence of Tdt) and positive (DNAse treatment) controls for TUNEL reaction, respectively (×400). Kidney International 2000 57, 437-445DOI: (10.1046/j.1523-1755.2000.00863.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 3 Percentage of apoptotic cells in sections of parathyroid tissue. Number of apoptotic (TUNEL positive) cells per 1000 parathyroid cells in tissues from normal human control subjects, and in tissues from patients with 1° hyperparathyroidism and 2° hyperparathyroidism. Data are expressed as means ± SEM. *P < 0.009, 1° hyperparathyroidism (N = 19) vs. normal (N = 13); **P < 0.005, 2° hyperparathyroidism (N = 11) vs. normal. Kidney International 2000 57, 437-445DOI: (10.1046/j.1523-1755.2000.00863.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 4 Immunostaining of Bcl-2 in nodular parathyroid hyperplasia. Focal decrease of Bcl-2 staining in tissue section corresponding to nodular area (lower part) compared with staining in diffusely hyperplastic area (upper part) of parathyroid gland of a patient with 2° hyperparathyroidism (×400). Kidney International 2000 57, 437-445DOI: (10.1046/j.1523-1755.2000.00863.x) Copyright © 2000 International Society of Nephrology Terms and Conditions