Volume 135, Issue 4, Pages 1106-1113 (October 2008) Natural History of Pediatric Crohn's Disease: A Population-Based Cohort Study  Gwenola Vernier–Massouille, Mamadou Balde, Julia Salleron, Dominique Turck, Jean Louis Dupas, Olivier Mouterde, Véronique Merle, Jean Louis Salomez, Julien Branche, Raymond Marti, Éric Lerebours, Antoine Cortot, Corinne Gower–Rousseau, Jean Frédéric Colombel  Gastroenterology  Volume 135, Issue 4, Pages 1106-1113 (October 2008) DOI: 10.1053/j.gastro.2008.06.079 Copyright © 2008 AGA Institute Terms and Conditions

Figure 1 Crohn's disease location at diagnosis and maximal follow-up in 281 pediatric patients with complete digestive exploration. Disease site was recorded according to the Montreal classification with a slight modification (ileal location with cecal involvement was considered an L3 location). Percentage of patients with 3 affected segments increased significantly, from 27% at diagnosis to 40% at follow-up (P < .01). Gastroenterology 2008 135, 1106-1113DOI: (10.1053/j.gastro.2008.06.079) Copyright © 2008 AGA Institute Terms and Conditions

Figure 2 Crohn's disease behavior according to Montreal classification at diagnosis and follow-up in 404 pediatric patients. There was a dramatic change in the proportion of disease behavior subgroups, usually from nonpenetrating, nonstricturing disease (B1) to stricturing (B2) or penetrating disease (B3) (P < .01). Gastroenterology 2008 135, 1106-1113DOI: (10.1053/j.gastro.2008.06.079) Copyright © 2008 AGA Institute Terms and Conditions

Figure 3 Cumulative risk of first intestinal resection in 394 pediatric patients with Crohn's disease. Cumulative probability of surgery was 0.07 (95% CI: 0.05–0.09) at 1 year, 0.20 (95% CI: 0.16–0.24) at 3 years, and 0.34 (95% CI: 0.30–0.40) at 5 years from time of diagnosis. Gastroenterology 2008 135, 1106-1113DOI: (10.1053/j.gastro.2008.06.079) Copyright © 2008 AGA Institute Terms and Conditions