Moderators and mediators of effects of unloading shoes on knee pain in people with knee osteoarthritis: an exploratory analysis of the SHARK randomised.

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Moderators and mediators of effects of unloading shoes on knee pain in people with knee osteoarthritis: an exploratory analysis of the SHARK randomised controlled trial K.L. Paterson, J. Kasza, K.L. Bennell, T.V. Wrigley, B.R. Metcalf, P.K. Campbell, D.J. Hunter, R.S. Hinman Osteoarthritis and Cartilage Volume 26, Issue 2, Pages 227-235 (February 2018) DOI: 10.1016/j.joca.2017.11.002 Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Illustration of the mediation analysis which decomposes the “total” effect of footwear group on walking pain into the “indirect” effect of footwear group on pain (the effect of the treatment on the outcome that acts through the mediator) and the “direct” effect of footwear group on pain (the effect of the treatment on the outcome that does not act through the mediator). The p value for the indirect pathway needs to be significant for the variable to be considered to have mediated the effect of group on walking pain. KAM, knee adduction moment. Osteoarthritis and Cartilage 2018 26, 227-235DOI: (10.1016/j.joca.2017.11.002) Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Interaction between randomised footwear group and a) peak knee adduction moment (KAM), b) mass, c) foot posture index (FPI) and d) likelihood of neuropathic pain (painDETECT score) for walking pain. The solid line indicates the difference between unloading shoes and conventional shoes, with 95% confidence intervals indicated by the shaded area. Osteoarthritis and Cartilage 2018 26, 227-235DOI: (10.1016/j.joca.2017.11.002) Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions