PICRUSt analysis results of predicted functional pathways in the gut microbiota. PICRUSt analysis results of predicted functional pathways in the gut microbiota.

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PICRUSt analysis results of predicted functional pathways in the gut microbiota. PICRUSt analysis results of predicted functional pathways in the gut microbiota. Pathways are grouped based on the following categories: amino acid metabolism (blue), carbohydrate and lipid metabolism (yellow), and energy metabolism (green). The pathway abundance values for control (red) and Gly-MCA treatment (dark green) are representative of the amount of genes and normalized to the total number of genes present in a particular pathway from each sample. These pathways were also ordered by decreasing coverage, which was calculated based on the total possible amount of genes (according to the Metacyc database). The underlined predicted functional pathways highlighted were supported by metabolomics analyses of liver extracts. All pathways shown are significant according to LEfSe. LEfSe uses the Kruskal-Wallis test and also the Wilcoxon test at a cutoff of 0.05 to determine significant and biologically relevant pathways between two groups. Limin Zhang et al. mSystems 2016; doi:10.1128/mSystems.00070-16