Volume 90, Pages (January 2019)

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Volume 90, Pages 13-23 (January 2019) Behavioral and Physiological Signs for Pain Assessment in Preterm and Term Neonates During a Nociception-Specific Response: A Systematic Review Lance M. Relland, MD, PhD, Alison Gehred, MA, Nathalie L. Maitre, MD, PhD Pediatric Neurology Volume 90, Pages 13-23 (January 2019) DOI: 10.1016/j.pediatrneurol.2018.10.001 Copyright © 2019 Elsevier Inc. Terms and Conditions

FIGURE 1 Schematics for NIRS-based protocols, showing before (light gray), during (striped) and after (dark gray) the stimulus. Location of sensor is denoted in the lower right gray box for each respective study. SCA = skin conductance algesimeter. Pediatric Neurology 2019 90, 13-23DOI: (10.1016/j.pediatrneurol.2018.10.001) Copyright © 2019 Elsevier Inc. Terms and Conditions

FIGURE 2 Schematics for EEG-based protocols, showing before (light gray) and after (dark gray) the stimulus. Location of electrodes are denoted in the left (nasion on top) for each respective study. TF = time frequency analysis. Pediatric Neurology 2019 90, 13-23DOI: (10.1016/j.pediatrneurol.2018.10.001) Copyright © 2019 Elsevier Inc. Terms and Conditions

FIGURE 3 Relative association of behavioral and physiological components and pain scales to cortical activity. Each measure listed on the horizontal axis is compared to pain-related brain activity. The relative positivity and negativity along the vertical axis represents the degree of a positive and negative association, respectively. The size and color of each circle represents the relative quantity and quality, respectively, of data that contribute to each given association. (A) Association to the presence or absence of a pain-related cortical response; (B) association to the intensity of a pain-related cortical response. Pediatric Neurology 2019 90, 13-23DOI: (10.1016/j.pediatrneurol.2018.10.001) Copyright © 2019 Elsevier Inc. Terms and Conditions