Association between Genetic Variants in Pre-MicroRNAs and Survival of Early-Stage NSCLC Mi Jeong Hong, MS, Yi Young Choi, MS, Ji-Ae Jang, MS, Hye-Jin.

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Association between Genetic Variants in Pre-MicroRNAs and Survival of Early-Stage NSCLC Mi Jeong Hong, MS, Yi Young Choi, MS, Ji-Ae Jang, MS, Hye-Jin Jung, MS, Shin Yup Lee, MD, PhD, Won Kee Lee, PhD, Seung Soo Yoo, MD, Jaehee Lee, MD, Seung Ick Cha, MD, PhD, Chang Ho Kim, MD, PhD, Eungbae Lee, MD, PhD, Hyo-Sung Jeon, PhD, Ji Woong Son, MD, Jae Yong Park, MD, PhD Journal of Thoracic Oncology Volume 8, Issue 6, Pages 703-710 (June 2013) DOI: 10.1097/JTO.0b013e318288dc0a Copyright © 2013 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Overall survival and disease-free survival curves according to genotypes: (A) pre-miR-149 rs2292832 TC or CC vs. TT genotype; (B) pre-miR-196a rs11614913 CT or TT vs. CC genotype, and (C) the combined genotypes of the two polymorphisms (1 and 2 good genotypes vs. none of good genotypes). p values in the multivariate Cox hazard models. Journal of Thoracic Oncology 2013 8, 703-710DOI: (10.1097/JTO.0b013e318288dc0a) Copyright © 2013 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Effect of the rs2292832T>C genotypes on miR-149 expression. Glyceraldehyde 3-phosphate dehydrogenase and the small nuclear RNA U6 were used to normalize the expression of primary and mature miR-149, respectively. (A) Expression levels of primary and mature miR-149 in tumors and normal lung tissues. Expression levels of primary and mature forms of miR-149 by the rs2292832T>C genotypes in normal lung tissues (B) and tumor tissues (C). Data represent median and quartiles. *p = 0.02, **p = 0.01. Journal of Thoracic Oncology 2013 8, 703-710DOI: (10.1097/JTO.0b013e318288dc0a) Copyright © 2013 International Association for the Study of Lung Cancer Terms and Conditions