3 Things to Know About Novel Treatment Targets for Schizophrenia

Overview of Schizophrenia Pathophysiology

Interactions Between Symptom Domains of Schizophrenia

Schizophrenia A Disease of Brain Circuitry

Heterogeneity of Symptoms

DSM-5 Criteria for Schizophrenia

Rule Out Secondary Causes in Schizophrenia Differential Diagnosis

Schizophrenia Time Course

Treatment Targets in Schizophrenia

Established Treatments Targeting Dopamine

Adverse Effects Associated with Dopamine Blockade

Newly Approved Antipsychotic Agents

Lumateperone in Schizophrenia

Pimavanserin in Schizophrenia

Trace Amine-Associated Receptor 1 (TAAR1) in Schizophrenia

Evaluating Lu AF35700

Effects on Symptoms in Schizophrenia MIN-101

ENLIGHTEN-1 ALKS 3831

ENLIGHTEN-2 ALKS 3831

Advantages of New and Novel Agents

Glutamatergic Pathways

Concluding Remarks

Abbreviations