Survival and time to death of cynomolgus macaques following vaccination with AVA and subsequent lethal B. anthracis spore challenge (NHP preexposure prophylaxis.

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Presentation transcript:

Survival and time to death of cynomolgus macaques following vaccination with AVA and subsequent lethal B. anthracis spore challenge (NHP preexposure prophylaxis study). Survival and time to death of cynomolgus macaques following vaccination with AVA and subsequent lethal B. anthracis spore challenge (NHP preexposure prophylaxis study). Animals were immunized with serial dilutions of the human dose of AVA on days 0 and 28. Control animals were immunized with PBS. On day 70, all monkeys were challenged via inhalation with 200 LD50 of aerosolized B. anthracis spores. Animals were monitored for morbidity and mortality for 63 days postchallenge (survival up to 30 days postchallenge shown in the figure; no additional deaths occurred after that period). Overall group survival rates at the time of study termination are shown in parentheses. *, The survival rate was significantly greater than that in the control group (P < 0.0006). Boris Ionin et al. Clin. Vaccine Immunol. 2013; doi:10.1128/CVI.00099-13