Association of cryptococci with the brain endothelium requires Mpr1 in the tail-vein murine model. Association of cryptococci with the brain endothelium.

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Association of cryptococci with the brain endothelium requires Mpr1 in the tail-vein murine model. Association of cryptococci with the brain endothelium requires Mpr1 in the tail-vein murine model. (A) The percent survival of mice inoculated via a more direct route to the brain (tail vein) with the H99 and mpr1Δ strains revealed a dramatic improvement in survival of mice infected with the mpr1Δ strain. (B and C) CFUs representing the fungal burden in brains of mice following 12 h, 24 h, and 48 h (B) or 16 days (C) postinfection with the H99 and mpr1Δ strains revealed significantly less fungal burden in brains of mice infected by the mpr1Δ null strain. (D) The number of cryptococci that survived within brain parenchyma of mice following inoculation by direct intracranial injection of the wild-type and mpr1Δ strains revealed no significant differences between strains. (Asterisks correspond to P values. **, P = 0.008; ***, P < 0.001.)‏ Kiem Vu et al. mBio 2014; doi:10.1128/mBio.01101-14