CEVA SANTE ANIMALE GUMBORO DISEASE

1987 : Belgium, The Netherlands EPIDEMIOLOGY Form 1990 à 2000 : Big expension 1988 : France, UK, Germany, Jordan, Saudi Arabia, Egypt 1987 : Belgium, The Netherlands 1965 : USA 1989 : Greece, Portugal, Israel, India, South of Africa  1970 : West of Africa 1990 : Thaïland 1998 : Latine America

Clinical Signs Thigh linear haemorrhage Swollen, oedematous bursa of Fabricius Haemorragic bursa of Fabricius

Gumboro impact on Chicks Up to 2 or 3 weeks IMMUNODEPRESSION MORTALITY without mortality without Immunodepression The IMPACT will depend on the age of the chicks

Gumboro pressure at the farms Day old chick immunized through 14-24 Days old Chick 1 Day old Chick Vaccine virus 7-10 Days old Chick Field Virus Field Virus Day old chick are sensible to the Virus (Competition against the field and the vaccine) Day old chick immunized through Maternal Antibodies

Importance of the vaccination Date

Importance of the vaccination Date Antibody rate Passive Immunity Active Immunity OWN ANTIBODIES VACCINATION MATERNAL ANTIBODIES Protected chicks Vaccine intake Protection level limit Unprotected Chicks Day 1 ??? Age

Chicks Heterogeneity MDA Antibody rate Passive Immunity Active Immunity OWN ANTIBODIES OWN ANTIBODIES OWN ANTIBODIES OWN ANTIBODIES VACCINATION MATERNAL ANTIBODIES Protected chicks Vaccine intake Protection level limit Unprotected Chicks J1 ??? ??? ??? Age

It is a COMPETITION and only the best will succeed Field versus vaccine It is a COMPETITION and only the best will succeed The best is the one who is able to overcome good amount of maternally derived antibodies: the first to penetrate The best is the one who is able to quickly replicate : he will keep his advance The best is the more abondant : field virus : to be decreased by disinfection Vaccine virus : to be increased by the vaccine quality and the quality of its administration

CEVA Vaccines against GUMBORO Subclinical infection, with economical losses: Cevac® GUMBO L, Intermediate vaccine, strong protection and seroconversion Very virulent Gumboro, with acute mortality: Cevac® IBD L, classical virus with fast replication (intermediate + vaccine), the only able to give high and early protection against vv IBDV )

CEVA vaccination programs

CEVA vaccination programs

GUMBORO HISTORY 1965 reached the commercial eggs production No vv IBD in USA Emerged for the first time in USA in 1957 1965 reached the commercial eggs production 1976 mortality was controlled through vaccination