A neonatal swine model for peanut allergy

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Presentation transcript:

A neonatal swine model for peanut allergy Ricki M. Helm, PhDa, Glenn T. Furuta, MDb, J.Steve Stanley, PhDa, Jianhui Ye, PhDa, Gael Cockrell, BSa, Cathie Connaughton, BSa, Pippa Simpson, PhDc, Gary A. Bannon, PhDa,d, A.Wesley Burks, MDa Journal of Allergy and Clinical Immunology Volume 109, Issue 1, Pages 136-142 (January 2002) DOI: 10.1067/mai.2002.120551 Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 1 Flow diagram shows the experimental regime. Journal of Allergy and Clinical Immunology 2002 109, 136-142DOI: (10.1067/mai.2002.120551) Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 2 Representative photographs of skin test results. Upper panel: Skin test results 1 week after a positive oral challenge with peanut meal. Lower panel: Skin test results from a nonsensitized piglet. Journal of Allergy and Clinical Immunology 2002 109, 136-142DOI: (10.1067/mai.2002.120551) Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 3 Intradermal skin challenge in peanut-sensitized and control swine at day 45. The mean for 7 peanut-sensitized animals (○) and the mean for 2 control animals (*) are represented. Representative P values are shown at the top of the figure. Identical values appear only once each. Journal of Allergy and Clinical Immunology 2002 109, 136-142DOI: (10.1067/mai.2002.120551) Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 4 Peanut-specific IgG levels in peanut-sensitized and control swine. Results are expressed as the means for 7 animals (○) in the peanut-sensitized group and 2 control animals (*). Represent-ative P values are shown at the top of the figure. Identical values appear only once each. Journal of Allergy and Clinical Immunology 2002 109, 136-142DOI: (10.1067/mai.2002.120551) Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 5 Histologic assessments of the small intestine in peanut-sensitized and nonsensitized control swine. A, Peanut-sensitized piglet after an oral challenge with peanut. B, Peanut-sensitized piglet that did not receive an oral challenge with peanut. Vascular congestion and edema of the mucosa and submucosa are evident in the sensitized swine sections (10×). Journal of Allergy and Clinical Immunology 2002 109, 136-142DOI: (10.1067/mai.2002.120551) Copyright © 2002 Mosby, Inc. Terms and Conditions