James D. House, Margaret E. Brosnan, John T. Brosnan

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Renal uptake and excretion of homocysteine in rats with acute hyperhomocysteinemia James D. House, Margaret E. Brosnan, John T. Brosnan Kidney International Volume 54, Issue 5, Pages 1601-1607 (November 1998) DOI: 10.1046/j.1523-1755.1998.00144.x Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 1 Effect of exposure time to a 80:20% nitrous oxide:oxygen gas atmosphere on total plasma homocysteine concentrations (μm) and kidney cystathionine β-synthase and methionine synthase activities [nmol/(mg protein ·hr) in rats. Data are means plus sem (N = 3 per time point). Different letter superscripts within a bar series denote statistically significant differences (P < 0.05) as assessed by ANOVA and Student-Newman-Keul's multiple comparisons procedure. Symbols are: (▪) plasma total homocysteine; () kidney cystathione β-synthase; (□) kidney methionine synthase. Kidney International 1998 54, 1601-1607DOI: (10.1046/j.1523-1755.1998.00144.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 2 Regression analysis of arterial plasma total homocysteine concentration versus renal homocysteine uptake. Data represent results from rats from three treatment groups: control, +HCY, +N2O. Regression equation: y = 0.37x + 0.55; P < 0.05, r2 = 0.62; N = 23. Kidney International 1998 54, 1601-1607DOI: (10.1046/j.1523-1755.1998.00144.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 1601-1607DOI: (10. 1046/j. 1523-1755 Kidney International 1998 54, 1601-1607DOI: (10.1046/j.1523-1755.1998.00144.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 1601-1607DOI: (10. 1046/j. 1523-1755 Kidney International 1998 54, 1601-1607DOI: (10.1046/j.1523-1755.1998.00144.x) Copyright © 1998 International Society of Nephrology Terms and Conditions