Optimal Experimental Design

Slides:

Advertisements

Similar presentations

Clinical Pharmacokinetics

Advertisements

“Calculating Drip Rates”

All Hands Meeting, 2006 Title: Grid Workflow Scheduling in WOSE (Workflow Optimisation Services for e- Science Applications) Authors: Yash Patel, Andrew.

Quick Studies? An Investigation Into “Learning” Based on the NFL Draft By Christopher Ferraro and Jacob Leibenluft.

Pharmacokinetics Questions

Laplace transformation

Practical Pharmacokinetics

Practical Pharmacokinetics September 11, 2007 Frank F. Vincenzi.

The General Concepts of Pharmacokinetics and Pharmacodynamics Hartmut Derendorf, PhD University of Florida.

10/13/20151Prof. Mazen Qato. OBJECTIVES 10/13/2015Prof. Mazen Qato2.

Pharmacokinetics and pharmacodynamics of gentamicin and vancomycin

Intravenous Infusion Previous rates of administration were instantaneous IV bolus and first order absorption. As a rate (mg/hr) a first order rate constantly.

Multiple dosing: intravenous bolus administration

1 Single-dose kinetics Plasma [Drug] curve Upon administration [drug] plasma reaches a max Then begins to decline as the Drug is eliminated Cp max = max.

CLINICAL PHARMACOKINETICS OF LIDOCAINE

1. Fate of drugs in the body 1.1 absorption 1.2 distribution - volume of distribution 1.3 elimination - clearance 2. The half-life and its uses 3. Repeated.

Continuous intravenous infusion (one-compartment model)

Principles of pharmacokinetics Prof. Kršiak Department of Pharmacology, Third Faculty of Medicine, Charles University in Prague Cycle II, Subject: General.

Therapeutic drug Monitoring

Theophylline in broncial asthma. By:Heba Othman Essam El-Din Pharm –D4(2009).

The General Concepts of Pharmacokinetics and Pharmacodynamics

Algebra II.  To remember everything in 1 st Semetser!

Learning objectives To know what data is available from pharmacokinetic studies in man and how to handle it To know how to calculate the basic pharmacokinetic.

Pharmacokinetic Questions

Division of Pharmacokinetics and Drug Therapy Department of Pharmaceutical Biosciences Uppsala University Sweden Sequential versus Simultaneous.

INTRODUCTION TO PHARMACOKINETICS M. Kršiak Department of Pharmacology, Third Faculty of Medicine, Charles University in Prague, Charles University in Prague,

Supplementary Table 1 C min of Teicoplanin at 1 st and 2 nd TDM in patients with administration of additional loading dose on the 4 th day Teicoplanin.

Connect with the author at facebook.com/ChristianA.Schwarz Leadership & Community Conference.

Fig. 2. Distribution of vitamin D levels of all samples by Siemens, Abbott, and DiaSorin. The mean (SD) of Siemens, Abbott, and DiaSorin assays was

Pharmacokinetics Tutoring

From: Cost-Optimized FPSO Mooring Design Via Harmony Search

Pharmacokinetics Tutoring

Assay and Error issues in Pop modeling and TDM

Multiple Model Dosage Design

Risk of Treatment Failure: Patient Support approaches and strategies

“Calculating Drip Rates”

Old and Newer methods for Bayesian updating

Quantitative of protein

Parametric and Nonparametric Population Modeling: a brief Summary

HPLC tracings of resveratrol (RV) and its major sulfate conjugates M4/M5 in the plasma from three subjects. HPLC tracings of resveratrol (RV) and its major.

Pralidoxime for organophosphate poisoning

Insulin Use in Primary Care: Practice Challenges

Activation of Phosphoinositide 3-Kinase γ by Ras

Case Progression: ABCD Survey

Distribution-Sensitive Learning for Imbalanced Datasets

Therapeutic Drug Monitoring chapter 1 part 1

Serum concentration of cartilage oligomeric matrix protein (COMP) is sensitive to physiological cyclic loading in healthy adults Annegret Mündermann,

Loading… Please Wait $ $ $100 $100 $100 $100 $100 $200 $200 $200 $200 $300 $300 $300 $300 $300 $400 $400 $400 $400 $400 $500 $500 $500 $500 $500.

Multiple ORAL Dosing Objectives

Online feedback–controlled renal constant infusion clearances in rats

C.2.10 Sample Questions.

C.2.8 Sample Questions.

Theophylline Dose-dumping

C.2.8 Sample Questions.

Post-Transcriptional Regulation of UV Induced TNF-α Expression

Experimental protocol for days 2, 3 and 4.

Drug Metabolism.

FIGURE 2 Stable isotope infusion protocol

Michael J. Lee, Henrik G. Dohlman Current Biology

Within-Subject Variability of Insulin Exposure and Metabolic Activity Following Replicate Doses of Technosphere® Insulin Inhalation Powder (TI) in Patients.

BCR–ABL kinase activity rewires GM-CSFR signaling and confers oncogene addiction in TF1 cells. BCR–ABL kinase activity rewires GM-CSFR signaling and confers.

EULAR Study Group: Therapeutic Drug Monitoring of Biopharmaceuticals in Rheumatology Aim of the study group To understand the required clinical and economic.

Dosage Calculation of Critical Care Medications: mg/min

Suppression of melanoma cell proliferation in response to kinase inhibitors. Suppression of melanoma cell proliferation in response to kinase inhibitors.

Examining the Role of Pharmacokinetics in Hemophilia

Expression of dominant-negative RasN17 completely suppresses Ras activation in Rh1 cells. Expression of dominant-negative RasN17 completely suppresses.

Distribution of SDS for serum creatinine, serum BUN, SBP, and DBP per quintiles of KS. Quintiles are expressed in SDS (see Figure 1B): 1st quintile,

Average trastuzumab serum concentrations in female minipigs following single subcutaneous administration of trastuzumab in formulations without and with.

Presentation transcript:

Optimal Experimental Design Optimal Times to get Serum Samples: D - optimal experimental Design 4/29/2019 USC LAPK

4/29/2019 USC LAPK

4/29/2019 USC LAPK

4/29/2019 USC LAPK

4/29/2019 USC LAPK

4/29/2019 USC LAPK

4/29/2019 USC LAPK

4/29/2019 USC LAPK

4/29/2019 USC LAPK

An Example: Monitoring Lidocaine Optimally Loading infusion over 1 min, then 1.45 mg/min. 10 subjects. Conventional monitoring strategy – 8 measurements, at 5, 10, 30, 60, 120, 180, 360, and 720 min into the regimen. V=30L, Kel=.0242hr-1, Kcp=.066hr-1, and Kpc=.038hr-1. Assay SD = 0.0078 + 0.1236 x conc. D – Optimal strategy – 4 samples, each in duplicate, at 1, 10, 70, and 720 min. 4/29/2019 USC LAPK

4/29/2019 USC LAPK

4/29/2019 USC LAPK

4/29/2019 USC LAPK

Bottom line for research or for TDM Don’t wait for steady state Don’t wait for distribution after the dose Start TDM with 1st dose Use D-opt principles 4/29/2019 USC LAPK