Recent advances in intravenous anaesthesia

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Recent advances in intravenous anaesthesia Sneyd J.R. British Journal of Anaesthesia Volume 93, Issue 5, Pages 725-736 (November 2004) DOI: 10.1093/bja/aeh253 Copyright © 2004 British Journal of Anaesthesia Terms and Conditions

Fig 1 THRX-918661 is a short-acting novel i.v. anaesthetic agent which has been evaluated in various animal models.163450 Its formula is probably [4-[(N,N-diethylcarbamoyl)methoxy]-3-ethoxyphenyl]acetic acid propyl ester. A likely structure is shown.51 British Journal of Anaesthesia 2004 93, 725-736DOI: (10.1093/bja/aeh253) Copyright © 2004 British Journal of Anaesthesia Terms and Conditions

Fig 2 Sulfobutyl ether-β-cyclodextrin (Captisol), a polyanionic β-cyclodextrin derivative with a sodium sulfonate salt separated from the lipophilic cavity by a butyl ether spacer group. Captisol has been used as a lipid-free vehicle for propofol.32 British Journal of Anaesthesia 2004 93, 725-736DOI: (10.1093/bja/aeh253) Copyright © 2004 British Journal of Anaesthesia Terms and Conditions

Fig 3 Predicted blood propofol concentrations after a 120 min infusion of propofol 4 mg kg−1 h−1 into a 20 kg child aged 5 yr. Four pharmacokinetic models are compared. Plots represent, from top to bottom: Marsh61 and Gepts37 Diprifusor model, mostly based on adult data; Rigby-Jones85 model, postcardiac surgery; Paedfusor;1 and Schuttler.93 Thick solid line shows pooled analysis including data from healthy children. British Journal of Anaesthesia 2004 93, 725-736DOI: (10.1093/bja/aeh253) Copyright © 2004 British Journal of Anaesthesia Terms and Conditions

Fig 4 Context-sensitive half-times after propofol infusions of various lengths into a 20 kg child aged 5 yr. Plots represent, from bottom to top: Marsh61 and Gepts37 Diprifusor model, mostly based on adult data; Rigby-Jones85 model, paediatric, postcardiac surgery; Paedfusor;1 and Schuttler.93 Thick solid line shows pooled analysis including data from healthy children. British Journal of Anaesthesia 2004 93, 725-736DOI: (10.1093/bja/aeh253) Copyright © 2004 British Journal of Anaesthesia Terms and Conditions