Higher Interleukin-7 serum concentrations in patients with cystic fibrosis correlate with impaired lung function Julia Seyfarth, Sutharsan Sivagurunathan,

Slides:

Advertisements

Similar presentations

Volume 62, Issue 6, Pages (June 2015)

Advertisements

Sleep quality and depression–anxiety in mothers of children with two chronic respiratory diseases: Asthma and cystic fibrosis Ozge Yılmaz, Ayhan Sogut,

Reduced levels of active GLP-1 in patients with cystic fibrosis with and without diabetes mellitus Magnus Hillman, Leif Eriksson, Lena Mared, Karin Helgesson,

Infections in Patients with Cystic Fibrosis

Hanneke A. de Valk, Corné H. W

CFTR mutation in an Arab patient: Clinical and functional features of 875+1G→A/875+1G→A genotype Elide Spinelli, Manuela Seia, Paola Melotti, Eleonora.

Is infection with hypermutable Pseudomonas aeruginosa clinically significant? Adi Auerbach, Eitan Kerem, Marc Victor Assous, Elie Picard, Maskit Bar-Meir

Platelet proinflammatory activity in clinically stable patients with CF starts in early childhood Alexander Sturm, Helge Hebestreit, Corinne Koenig,

Zachary M. Sellers, Lori McGlocklin, Andrea Brasch

Early rise of anti-Pseudomonas antibodies and a mucoid phenotype of Pseudomonas aeruginosa are risk factors for development of chronic lung infection—A.

How does heart rate recovery after sub-maximal exercise correlate with maximal exercise testing in children with CF? Sarah P. Cohen, David M. Orenstein

Scott D. Sagel, Marci K. Sontag, Meg M

Pseudomonas aeruginosa in cystic fibrosis: Pyocyanin negative strains are associated with BPI-ANCA and progressive lung disease Malin Carlsson, Swati.

Oxidative stress in stable cystic fibrosis patients: Do we need higher antioxidant plasma levels? Antonela Lezo, Fiorella Biasi, Paola Massarenti, Roberto.

Comparison of two treatment regimens for eradication of Pseudomonas aeruginosa infection in children with cystic fibrosis M. Proesmans, F. Vermeulen,

Sleep quality and depression–anxiety in mothers of children with two chronic respiratory diseases: Asthma and cystic fibrosis Ozge Yılmaz, Ayhan Sogut,

Laura Viviani, Baroukh M. Assael, Eitan Kerem

Statistical limitations of percent ideal body weight as measure for nutritional failure in patients with cystic fibrosis T.O. Hirche, H. Hirche, S. Jungblut,

A longitudinal analysis of chronic MRSA and Pseudomonas aeruginosa co-infection in cystic fibrosis: A single-center study Maret L. Maliniak, Arlene A.

Katelyn Krivchenia, Don Hayes, Joseph D. Tobias, Dmitry Tumin

Rate of improvement of CF life expectancy exceeds that of general population— Observational death registration study Matthew N. Hurley, Tricia M. McKeever,

Increased serum concentration of G-CSF in cystic fibrosis patients with chronic Pseudomonas aeruginosa pneumonia P.Ø. Jensen, C. Moser, A. Kharazmi,

Autoantibody response to BPI predict disease severity and outcome in cystic fibrosis Malin Carlsson, Leif Eriksson, Tania Pressler, Ragnhild Kornfält,

Amanda L. Brennan, Khin M. Gyi, David M

A cohort study of the Copenhagen CF Centre eradication strategy against Staphylococcus aureus in patients with CF Christina Schjellerup Dalbøge, Tacjana.

Clinical outcomes in cystic fibrosis patients with Trichosporon respiratory infection Charles R. Esther, Rongpong Plongla, Alan Kerr, Feng-Chang Lin,

Controlled clinical trials in cystic fibrosis — are we doing better?

Lucas R. Hoffman, Hemantha D. Kulasekara, Julia Emerson, Laura S

Long-term azitromycin treatment of cystic fibrosis patients with chronic Pseudomonas aeruginosa infection; an observational cohort study Christine Rønne.

Advanced glycation end products are elevated in cystic fibrosis-related diabetes and correlate with worse lung function William R. Hunt, Beth R. Helfman,

Significance of human β-defensins in the epithelial lining fluid of patients with chronic lower respiratory tract infections S. Yanagi, J. Ashitani,

Gerd Döring, Patrick Flume, Harry Heijerman, J. Stuart Elborn

Implementation of European standards of care for cystic fibrosis �� Control and treatment of infection J.S. Elborn, M. Hodson, C. Bertram Journal of.

Vitamin A and lung function in CF

A.H. Gifford Journal of Cystic Fibrosis

Oxidized glutathione and uric acid as biomarkers of early cystic fibrosis lung disease Nina Dickerhof, Rufus Turner, Irada Khalilova, Emmanuelle Fantino,

Demographics of glucose metabolism in cystic fibrosis

Differences in prevalence and treatment of Pseudomonas aeruginosa in cystic fibrosis centres in Denmark, Norway and Sweden Per Kristian Knudsen, Hanne.

Economic effects of an eradication protocol for first appearance of Pseudomonas aeruginosa in cystic fibrosis patients: 1995 vs. 2009 Yolanda P. Lillquist,

Effectiveness of inhaled tobramycin in eradicating Pseudomonas aeruginosa in children with cystic fibrosis Sanja Stanojevic, Valerie Waters, Joseph L.

M. Al-Aloul, M. Jackson, G. Bell, M. Ledson, M. Walshaw

Cytokine gene polymorphisms and severity of CF lung disease

Nasal polyposis in lung transplant recipients with cystic fibrosis

Chee Y. Ooi, Peter R. Durie Journal of Cystic Fibrosis

Inflammatory and immunological biomarkers are not related to survival in adults with Cystic Fibrosis K.L. Moffitt, S.L. Martin, A.M. Jones, A.K. Webb,

Novel concepts in evaluating antimicrobial therapy for bacterial lung infections in patients with cystic fibrosis Geraint B. Rogers, Lucas R. Hoffman,

Australian epidemic strain pseudomonas (AES-1) declines further in a cohort segregated cystic fibrosis clinic Amanda L. Griffiths, Danielle F. Wurzel,

Nutritional decline in cystic fibrosis related diabetes: The effect of intensive nutritional intervention H. White, K. Pollard, C. Etherington, I. Clifton,

Segregation of children with CF diagnosed via newborn screening and acquisition of Pseudomonas aeruginosa Karen O. McKay, Peter J. Cooper, Peter P. van.

Trends in pathogens colonising the respiratory tract of adult patients with cystic fibrosis, 1985–2005 F.A. Millar, N.J. Simmonds, M.E. Hodson Journal.

F. Vermeulen, P. Lebecque, K. De Boeck, T. Leal

A. Sapet, A. C. Normand, M. Oudyi, N. Stremler- Le Bel, R. Piarroux, J

V. Thompson, N. Mayer-Hamblett, M. Kloster, D. Bilton, P.A. Flume

Determining presence of lung disease in young children with cystic fibrosis: Lung clearance index, oxygen saturation and cough frequency E.M. Bakker,

Diabetes mellitus and survival in cystic fibrosis patients after lung transplantation Markus Hofer, Christoph Schmid, Christian Benden, Rudolf Speich,

Stability of interleukin 8 and neutrophil elastase in bronchoalveolar lavage fluid following long-term storage Luke J. Berry, Barbara Sheil, Luke Garratt,

Soluble inflammation markers in nasal lavage from CF patients and healthy controls Natalie Beiersdorf, Matthias Schien, Julia Hentschel, Wolfgang Pfister,

J.E. Spahr, R.B. Love, M. Francois, K. Radford, K.C. Meyer

Michael W. Konstan, David J. Pasta, Jeffrey S. Wagener, Donald R

Serum-surfactant SP-D correlates inversely to lung function in cystic fibrosis Hanne Vebert Olesen, Uffe Holmskov, Peter Oluf Schiøtz, Grith Lykke Sørensen

C. R. Hansen, T. Pressler, K. G. Nielsen, P. Ø. Jensen, T

The role of respiratory viruses in adult patients with cystic fibrosis receiving intravenous antibiotics for a pulmonary exacerbation C. Etherington,

CFTR modulators and pregnancy: Our work has only just begun

Increasing resistance of the Liverpool Epidemic Strain (LES) of Pseudomonas aeruginosa (Psa) to antibiotics in cystic fibrosis (CF)—A cause for concern?

Elisabeth P. Dellon, Margaret W. Leigh, James R. Yankaskas, Terry L

Improved early diagnosis of Pseudomonas aeruginosa by real-time PCR to prevent chronic colonisation in a paediatric cystic fibrosis population Elaine.

Absence of a gender gap in survival

Cystic fibrosis and pregnancy in the modern era: A case control study

R. D. Gray, M. Imrie, A. C. Boyd, D. Porteous, J. A. Innes, A. P

Early aggressive eradication therapy for intermittent Pseudomonas aeruginosa airway colonization in cystic fibrosis patients: 15 years experience C.R.

Presentation transcript:

Higher Interleukin-7 serum concentrations in patients with cystic fibrosis correlate with impaired lung function Julia Seyfarth, Sutharsan Sivagurunathan, Sarah Ricken, Gerhard Weinreich, Laura Olbrich, Christian Taube, Ertan Mayatepek, Dirk Schramm, Marc Jacobsen Journal of Cystic Fibrosis Volume 18, Issue 1, Pages 71-77 (January 2019) DOI: 10.1016/j.jcf.2018.09.008 Copyright © 2018 European Cystic Fibrosis Society Terms and Conditions

Fig. 1 IL-7 serum levels in patients with cystic fibrosis (CF) and healthy controls. (A, B) IL-7 serum levels of patients with CF (n = 164) and healthy controls (n = 60) as well as for age-matched subgroups of CF patients (CFadult: n = 130; CFyouth: n = 34 and controls (B). Median values are indicated. Nominal p-values for the Mann-Whitney U test (two-tailed) are given. Journal of Cystic Fibrosis 2019 18, 71-77DOI: (10.1016/j.jcf.2018.09.008) Copyright © 2018 European Cystic Fibrosis Society Terms and Conditions

Fig. 2 Effects of clinical features and infections of CF patients on IL-7 serum concentrations. (A) IL-7 serum levels for CF patients with or without Pseudomonas (P.) aeruginosa, Aspergillus (A.) fumigatus, or Staphylococcus (S.) aureus infection. IL-7 serum levels in patients chronically infected with P. aeruginosa (left graph; negative: n = 95, positive: n = 69), A. fumigatus (middle graph; negative: n = 126, positive: n = 38), and S. aureus (right graph; negative: n = 99, positive: n = 65) are shown. Median values for groups and nominal p-values for the Mann-Whitney U test (two-tailed) are indicated. (B) CF patients BMI (left graph, n = 154) and FEV1%pred (right graph, n = 155) were correlated with serum IL-7. Spearman's rank correlation coefficient r and the respective p-values are indicated. A trend line was fitted by linear regression analysis. (C) IL-7 serum levels are shown for CF patient subgroups classified according to pancreatic insufficiency (left graph, no: n = 142; yes: n = 22) and diabetes (right graph, no: n = 87; yes: n = 77). Median values for groups and nominal p-values for the Mann-Whitney U test (two-tailed) are indicated. Journal of Cystic Fibrosis 2019 18, 71-77DOI: (10.1016/j.jcf.2018.09.008) Copyright © 2018 European Cystic Fibrosis Society Terms and Conditions

Fig. 3 Time course analyses of IL-7 serum concentrations and clinical features for a subgroup of CF patients (n = 78). (A) CF patients FEV1%pred (left graph) and BMI (right graph) are shown for both time points (B). IL-7 serum concentrations are shown for both time points. CF patients shown for time point (TP)2 were recruited 1 year +/- 6 months after TP1. (A, B) Median values for groups and nominal p-values for the Mann-Whitney U test (two-tailed) are indicated. (C) CF patients FEV1%pred (left graph) and BMI (right graph) are correlated with IL-7 serum concentration at the second time point. Spearman's rank correlation coefficient r and the respective p-values are indicated. A trend line was fitted by linear regression analysis. Journal of Cystic Fibrosis 2019 18, 71-77DOI: (10.1016/j.jcf.2018.09.008) Copyright © 2018 European Cystic Fibrosis Society Terms and Conditions