Hematopoietic Engraftment in Recipients of Unrelated Donor Umbilical Cord Blood Is Affected by the CD34+ and CD8+ Cell Doses Seitaro Terakura, Eiichi.

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Hematopoietic Engraftment in Recipients of Unrelated Donor Umbilical Cord Blood Is Affected by the CD34+ and CD8+ Cell Doses Seitaro Terakura, Eiichi Azuma, Makoto Murata, Tadashi Kumamoto, Masahiro Hirayama, Yoshiko Atsuta, Yoshihisa Kodera, Makoto Yazaki, Tomoki Naoe, Koji Kato Biology of Blood and Marrow Transplantation Volume 13, Issue 7, Pages 822-830 (July 2007) DOI: 10.1016/j.bbmt.2007.03.006 Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 UCB graft cell dose. Box plot for cell doses of each cell fraction. The horizontal bar within each box plot indicates the median of the contained cell number. The top and bottom of the box indicates the 25th and 75th percentiles, respectively. The top and bottom of the whisker indicates the 5th and 95th percentiles, respectively. Biology of Blood and Marrow Transplantation 2007 13, 822-830DOI: (10.1016/j.bbmt.2007.03.006) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Cumulative incidence of engraftment. A, Cumulative incidence of engraftment in the patients who received more than median dose of CD34+ cells (>1.4 × 105/kg). The solid line indicates the patients receiving more than the median dose of CD8+ cells (>15.7 × 105/kg), and the dotted line indicates the patients receiving a median or lower dose of CD8+ cells (<15.7 × 105/kg). The overall incidences of engraftment in each patient group were 0.93 (n = 53) and 0.85 (n = 20), respectively. B, Cumulative incidence of engraftment in the patients who received a median or lower dose of CD34+ cells (≤1.4 × 105/kg). The solid line indicates the patients receiving more than the median dose of CD8+ cells, and the dotted line indicates the patients receiving a median or lower dose of CD8+ cells. The overall incidences of engraftment in each patient group were 0.90 (n = 20) and 0.66 (n = 53), respectively. Biology of Blood and Marrow Transplantation 2007 13, 822-830DOI: (10.1016/j.bbmt.2007.03.006) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions