The immunopharmacology of mild asthma

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Presentation transcript:

The immunopharmacology of mild asthma Stephen T. Holgate, MD, DSc, FRCP(Lond), FRCP(Edin) Journal of Allergy and Clinical Immunology Volume 98, Issue 5, Pages S7-S16 (November 1996) DOI: 10.1016/S0091-6749(96)70011-8 Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 1 Diagrammatic representation of cytokine networks involved in the regulation of allergic inflammation. Journal of Allergy and Clinical Immunology 1996 98, S7-S16DOI: (10.1016/S0091-6749(96)70011-8) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 2 Transcription of IL-5 by highly purified (>98%) human lung mast calls in the presence (+) and absence (-) of antihuman IgE. The time course of the PCR products (upper panel) are compared with the time course of histamine and IL-5 product release. Mast cells were preincubated with a low concentration of stem cell factor (10 ng/ml). Journal of Allergy and Clinical Immunology 1996 98, S7-S16DOI: (10.1016/S0091-6749(96)70011-8) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 2 Transcription of IL-5 by highly purified (>98%) human lung mast calls in the presence (+) and absence (-) of antihuman IgE. The time course of the PCR products (upper panel) are compared with the time course of histamine and IL-5 product release. Mast cells were preincubated with a low concentration of stem cell factor (10 ng/ml). Journal of Allergy and Clinical Immunology 1996 98, S7-S16DOI: (10.1016/S0091-6749(96)70011-8) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 3 Diagrammatic representations of targets for the action of mast cell tryptase pertinent to the airway inflammation of asthma. Journal of Allergy and Clinical Immunology 1996 98, S7-S16DOI: (10.1016/S0091-6749(96)70011-8) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 4 Interactions between immunologic, inflammatory, and remodeling processes in determining the severity and chronicity of asthma. Journal of Allergy and Clinical Immunology 1996 98, S7-S16DOI: (10.1016/S0091-6749(96)70011-8) Copyright © 1996 Mosby, Inc. Terms and Conditions