Idiopathic capillary leak syndrome: Evidence of CD8-positive lymphocytes surrounding damaged endothelial cells Marco Cicardi, MDa, Emilio Berti, MDb,

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Idiopathic capillary leak syndrome: Evidence of CD8-positive lymphocytes surrounding damaged endothelial cells Marco Cicardi, MDa, Emilio Berti, MDb, Valentina Caputo, MDc, Ferdinando Radice, MDc, Marco Gardinali, MDa, Angelo Agostoni, MDa Journal of Allergy and Clinical Immunology Volume 99, Issue 3, Pages 417-419 (March 1997) DOI: 10.1016/S0091-6749(97)70061-7 Copyright © 1997 Mosby, Inc. Terms and Conditions

FIG. 1 A, Hematoxylin-eosin–stained skin section showing a mononuclear lymphoid infiltrate around a vessel in superficial dermis. B, Immunohistochemistry (anti-CD8-APAAP staining) of the same area showing several CD8-positive lymphocytes. C, Immunohistochemistry (anti-CD3-APAAP staining) showing T lymphocytes around vessels. D, Immunohistochemistry (anti-S-100-APAAP staining) showing many positive cells in epidermis and superficial dermis. Note the presence of some intravascular positive cells. E, Immunohistochemistry (anti-CD45RO-APAAP staining) showing that most lymphocytes are primed T cells. Journal of Allergy and Clinical Immunology 1997 99, 417-419DOI: (10.1016/S0091-6749(97)70061-7) Copyright © 1997 Mosby, Inc. Terms and Conditions

FIG. 1 A, Hematoxylin-eosin–stained skin section showing a mononuclear lymphoid infiltrate around a vessel in superficial dermis. B, Immunohistochemistry (anti-CD8-APAAP staining) of the same area showing several CD8-positive lymphocytes. C, Immunohistochemistry (anti-CD3-APAAP staining) showing T lymphocytes around vessels. D, Immunohistochemistry (anti-S-100-APAAP staining) showing many positive cells in epidermis and superficial dermis. Note the presence of some intravascular positive cells. E, Immunohistochemistry (anti-CD45RO-APAAP staining) showing that most lymphocytes are primed T cells. Journal of Allergy and Clinical Immunology 1997 99, 417-419DOI: (10.1016/S0091-6749(97)70061-7) Copyright © 1997 Mosby, Inc. Terms and Conditions

FIG. 1 A, Hematoxylin-eosin–stained skin section showing a mononuclear lymphoid infiltrate around a vessel in superficial dermis. B, Immunohistochemistry (anti-CD8-APAAP staining) of the same area showing several CD8-positive lymphocytes. C, Immunohistochemistry (anti-CD3-APAAP staining) showing T lymphocytes around vessels. D, Immunohistochemistry (anti-S-100-APAAP staining) showing many positive cells in epidermis and superficial dermis. Note the presence of some intravascular positive cells. E, Immunohistochemistry (anti-CD45RO-APAAP staining) showing that most lymphocytes are primed T cells. Journal of Allergy and Clinical Immunology 1997 99, 417-419DOI: (10.1016/S0091-6749(97)70061-7) Copyright © 1997 Mosby, Inc. Terms and Conditions

FIG. 1 A, Hematoxylin-eosin–stained skin section showing a mononuclear lymphoid infiltrate around a vessel in superficial dermis. B, Immunohistochemistry (anti-CD8-APAAP staining) of the same area showing several CD8-positive lymphocytes. C, Immunohistochemistry (anti-CD3-APAAP staining) showing T lymphocytes around vessels. D, Immunohistochemistry (anti-S-100-APAAP staining) showing many positive cells in epidermis and superficial dermis. Note the presence of some intravascular positive cells. E, Immunohistochemistry (anti-CD45RO-APAAP staining) showing that most lymphocytes are primed T cells. Journal of Allergy and Clinical Immunology 1997 99, 417-419DOI: (10.1016/S0091-6749(97)70061-7) Copyright © 1997 Mosby, Inc. Terms and Conditions

FIG. 1 A, Hematoxylin-eosin–stained skin section showing a mononuclear lymphoid infiltrate around a vessel in superficial dermis. B, Immunohistochemistry (anti-CD8-APAAP staining) of the same area showing several CD8-positive lymphocytes. C, Immunohistochemistry (anti-CD3-APAAP staining) showing T lymphocytes around vessels. D, Immunohistochemistry (anti-S-100-APAAP staining) showing many positive cells in epidermis and superficial dermis. Note the presence of some intravascular positive cells. E, Immunohistochemistry (anti-CD45RO-APAAP staining) showing that most lymphocytes are primed T cells. Journal of Allergy and Clinical Immunology 1997 99, 417-419DOI: (10.1016/S0091-6749(97)70061-7) Copyright © 1997 Mosby, Inc. Terms and Conditions