Figure 4 The relationship between the time-dependent changes in the expression of immunoglobulin, mast cell, acute kidney injury (AKI), and fibrillar collagen transcripts and the progression of tubular atrophy and interstitial fibrosis (TA/IF) Figure 4 | The relationship between the time-dependent changes in the expression of immunoglobulin, mast cell, acute kidney injury (AKI), and fibrillar collagen transcripts and the progression of tubular atrophy and interstitial fibrosis (TA/IF). Data represent average molecular scores from 282 biopsy samples obtained within the first year post-transplantation. The left y-axis represents the average molecular scores of pathogenesis based transcript sets, and the right y-axis represents average histologic ci-scores (indicative of TA/IF). Modified with permission from the American Society for Clinical Investigation © Venner, J.M. et al. JCI Insight 1, e85323 (2016). Modified with permission from the American Society for Clinical Investigation © Venner, J.M. et al. JCI Insight 1, e85323 (2016). Halloran, P. F. et al. (2016) Molecular assessment of disease states in kidney transplant biopsy samples Nat. Rev. Nephrol. doi:10.1038/nrneph.2016.85