Fen Huang, Chenchen Yang, Xinying Zhou, Wenhai Yu, Qiuwei Pan

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Rhesus macaques persistently infected with hepatitis E shed virus into urine Fen Huang, Chenchen Yang, Xinying Zhou, Wenhai Yu, Qiuwei Pan Journal of Hepatology Volume 64, Issue 6, Pages 1446-1447 (June 2016) DOI: 10.1016/j.jhep.2015.12.026 Copyright © 2016 European Association for the Study of the Liver Terms and Conditions

Fig. 1 Rhesus macaques persistently infected with HEV shed virus into urine. Quantification of HEV genomic RNA in serum (A) and stool samples (B) from #1 and #2 monkeys was determined by qRT-PCR. (C) Measurement of serum HEV IgM and IgG levels by ELISA kit. (D) Measurement of serum ALT and AST levels. (E) Quantification of HEV genomic RNA in urine samples from #1 and #2 monkeys at 650 and 272days-post-inoculation (dpi), respectively. (F) Quantification of HEV genomic RNA in liver and kidney tissues of #1 monkey. (G) Histology of the liver tissue of #1 monkey with haematoxylin and eosin (HE) staining; 100×. Histology of the kidney tissue of #1 monkey with HE (H) and Periodic acid–Schiff (PAS) (I) staining, 200×. Details of methodology were provided in Supplementary information file. Journal of Hepatology 2016 64, 1446-1447DOI: (10.1016/j.jhep.2015.12.026) Copyright © 2016 European Association for the Study of the Liver Terms and Conditions