The role of histone deacetylases in asthma and allergic diseases

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Presentation transcript:

The role of histone deacetylases in asthma and allergic diseases Pankaj Bhavsar, PhD, Tehireem Ahmad, BSc, Ian M. Adcock, PhD Journal of Allergy and Clinical Immunology Volume 121, Issue 3, Pages 580-584 (March 2008) DOI: 10.1016/j.jaci.2007.12.1156 Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 A, Allergen exposure or inflammatory stimuli lead to histone acetylation (histones shown protruding through pale blue DNA loops) by HATs and gene induction/cell activation. This process is reversed by specific HDACs, which mediate the actions of glucocorticoids. Nonhistone proteins are also targets for lysine acetylation and deacetylation by HATS and HDACs, with the effect on cell function depending on stimulus, readout, and cell type. B, Selective HDACs and sirtuins (SIRT) can target acetylated proteins' GR functions either directly or indirectly through Hsp90 or by blocking HAT/NF-κB interactions (see main text for details). Journal of Allergy and Clinical Immunology 2008 121, 580-584DOI: (10.1016/j.jaci.2007.12.1156) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions