″Minor″ BCL2 Breakpoints in Follicular Lymphoma

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Presentation transcript:

″Minor″ BCL2 Breakpoints in Follicular Lymphoma Olga K. Weinberg, Weiyun Z. Ai, M. Rajan Mariappan, Carol Shum, Ronald Levy, Daniel A. Arber The Journal of Molecular Diagnostics Volume 9, Issue 4, Pages 530-537 (September 2007) DOI: 10.2353/jmoldx.2007.070038 Copyright © 2007 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

Figure 1 A map of breakpoint sites in relation to the IGH/BCL2 translocation. The Journal of Molecular Diagnostics 2007 9, 530-537DOI: (10.2353/jmoldx.2007.070038) Copyright © 2007 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

Figure 2 Survival curve of 149 patients with follicular lymphomas. Patients were divided into three groups according to the site of their BCL2 breakpoints. Minor breakpoints consisted of mcr, icr, 3′ BCL2, and 5′ mcr, as well as PCR-negative cases that tested positive with FISH for IGH/BCL2 fusion. Negative breakpoint group consisted of cases that tested negative by both PCR and FISH methods. The overall survival in three groups was comparable. The Journal of Molecular Diagnostics 2007 9, 530-537DOI: (10.2353/jmoldx.2007.070038) Copyright © 2007 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions