Ineffectiveness of Crizotinib on Brain Metastases in Two Cases of Lung Adenocarcinoma with EML4-ALK Rearrangement Denis Maillet, MD, Isabelle Martel-Lafay,

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Ineffectiveness of Crizotinib on Brain Metastases in Two Cases of Lung Adenocarcinoma with EML4-ALK Rearrangement Denis Maillet, MD, Isabelle Martel-Lafay, MD, Dominique Arpin, MD, Maurice Pérol, MD Journal of Thoracic Oncology Volume 8, Issue 4, Pages e30-e31 (April 2013) DOI: 10.1097/JTO.0b013e318288dc2d Copyright © 2013 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Abdominal computed tomography (A) before and (B) after 6 weeks of crizotinib showed a substantial decrease in the size of all liver metastases. C, D, and E, Magnetic resonance imaging T1 gadolinium at (A) initiation of crizotinib and after (B) 6 and (C)10 weeks of treatment showed an increase in size of the left frontal cerebral metastasis of 28 mm to 54 mm associated with the appearance of a right periventricular lesion. Journal of Thoracic Oncology 2013 8, e30-e31DOI: (10.1097/JTO.0b013e318288dc2d) Copyright © 2013 International Association for the Study of Lung Cancer Terms and Conditions