Persistent elevation of plasma thrombopoietin levels after treatment in severe aplastic anemia Xin Zhao, Xingmin Feng, Zhijie Wu, Thomas Winkler, Ronan.

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Presentation transcript:

Persistent elevation of plasma thrombopoietin levels after treatment in severe aplastic anemia Xin Zhao, Xingmin Feng, Zhijie Wu, Thomas Winkler, Ronan Desmond, Matthew Olnes, Bogdan Dumitriu, Danielle M. Townsley, Cynthia E. Dunbar, Neal S. Young Experimental Hematology Volume 58, Pages 39-43 (February 2018) DOI: 10.1016/j.exphem.2017.09.006 Copyright © 2018 Terms and Conditions

Figure 1 Longitudinal plasma EPO and G-CSF levels in severe AA patients. (A) EPO and G-CSF levels in treatment-naive patients (n = 37). Blue circles represent responders; red circles represent nonresponders. *p < 0.05; **p < 0.01; ***p < 0.001. (B) Follow-up of EPO levels and hemoglobin concentrations in complete responders to IST (n = 9). (C) Correlation of plasma EPO levels with hemoglobin concentrations in severe AA patients. (D) EPO and G-CSF levels in IST-refractory patients (n = 10). Error bar indicates mean and SEM for hemoglobin levels in (B) and median and interquartile in others. Experimental Hematology 2018 58, 39-43DOI: (10.1016/j.exphem.2017.09.006) Copyright © 2018 Terms and Conditions

Figure 2 Changes in plasma TPO levels over time in severe AA patients. TPO levels in treatment-naive (A) and IST-refractory patients (B). Blue circles represent responders; red circles represent nonresponders. *p < 0.05; **p < 0.01; ***p < 0.001. (C) Different levels of plasma TPO between severe AA patients (n = 10) and healthy donors (n = 8) validated by Western blotting (TPO antibody from Thermo Fisher Scientific). The intensities of bands were quantified and depicted in the bar graph. (D) Follow-up of TPO levels and platelet counts in complete responders to IST (n = 9). (E) Correlation of plasma TPO levels with platelet counts. Red dots and black dots represent complete responders and nonresponders from treatment-naive group, respectively; blue dots represent IST-refractory patients; green dots represent healthy controls. Dots within the square were compared for TPO levels between patients and healthy controls. Patient's samples from different time points at baseline and after treatment were all included in this figure. Error bar indicates mean and SEM for platelet count in (D) and median and interquartile in others. Experimental Hematology 2018 58, 39-43DOI: (10.1016/j.exphem.2017.09.006) Copyright © 2018 Terms and Conditions