Comparison of motor-evoked potentials monitoring in response to transcranial electrical stimulation in subjects undergoing neurosurgery with partial vs.

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Comparison of motor-evoked potentials monitoring in response to transcranial electrical stimulation in subjects undergoing neurosurgery with partial vs no neuromuscular block† W.H. Kim, J.J. Lee, S.M. Lee, M.N. Park, S.K. Park, D.W. Seo, I.S. Chung British Journal of Anaesthesia Volume 110, Issue 4, Pages 567-576 (April 2013) DOI: 10.1093/bja/aes395 Copyright © 2013 The Author(s) Terms and Conditions

Fig 1 A flow diagram showing the time course of the measurements obtained in the present study. British Journal of Anaesthesia 2013 110, 567-576DOI: (10.1093/bja/aes395) Copyright © 2013 The Author(s) Terms and Conditions

Fig 2 Study design according to CONSORT 2010 flow diagram. British Journal of Anaesthesia 2013 110, 567-576DOI: (10.1093/bja/aes395) Copyright © 2013 The Author(s) Terms and Conditions

Fig 3 Box plots of transcranial electrical MEP amplitude from both arms and legs obtained after train-of-five pulse transcranial electrical stimulation were shown. Each group aimed at the targets of a TOF of 2 (Group A), a T1/Tc of 0.5 (Group B), a T2/Tc of 0.5 (Group C), and no NMB (Group D). Tc is the control twitch response obtained before the administration of the neuromuscular blocking agent. T1 and T2 are the first and second twitch responses of the TOF stimulation of the ulnar nerve, respectively. Horizontal bars represent the 90th, 75th, median, 25th, and 10th percentile. *P<0.05 compared with Group A; †P<0.05 compared with Group B; ‡P<0.05 compared with Group C. British Journal of Anaesthesia 2013 110, 567-576DOI: (10.1093/bja/aes395) Copyright © 2013 The Author(s) Terms and Conditions

Fig 4 Box plots of the CV (%) of transcranial electrical MEP amplitudes from both arms and legs of all groups. Horizontal bars represent the 90th, 75th, median, 25th, and 10th percentile. The CV of the MEP amplitude (%) was calculated as the sd of the MEP amplitude divided by the mean MEP amplitude value. *P<0.05 compared with Group A; †P<0.05 compared with Group B; ‡P<0.05 compared with Group C. British Journal of Anaesthesia 2013 110, 567-576DOI: (10.1093/bja/aes395) Copyright © 2013 The Author(s) Terms and Conditions

Fig 5 MEP monitoring amplitude of the left arm and the left leg in 30 min intervals for 5 h after the baseline set-up. T0: the MEP monitoring baseline; T0.5, 30 min; T1, 1 h; T1.5, 1.5 h; T2, 2 h; T2.5, 2.5 h; T3, 3 h; T3.5, 3.5 h; T4, 4 h; T4.5, 4.5 h; T5, 5 h after the MEP baseline. British Journal of Anaesthesia 2013 110, 567-576DOI: (10.1093/bja/aes395) Copyright © 2013 The Author(s) Terms and Conditions