Cell Factory Engineering

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Presentation transcript:

Cell Factory Engineering Anne Mathilde Davy, Helene Faustrup Kildegaard, Mikael Rørdam Andersen Cell Systems Volume 4, Issue 3, Pages 262-275 (March 2017) DOI: 10.1016/j.cels.2017.02.010 Copyright © 2017 Elsevier Inc. Terms and Conditions

Cell Systems 2017 4, 262-275DOI: (10.1016/j.cels.2017.02.010) Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Ontology of Different Types of Cellular Engineering Covered in This Review Cell Systems 2017 4, 262-275DOI: (10.1016/j.cels.2017.02.010) Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 2 Engineering Strategies for Optimizing the Production of Native Metabolites Metabolites are denoted: S, substrate; S2, alternative substrate; X1-9, pathway intermediates; P, product of interest; BP, by-product. Generic engineering strategies are marked in blue and annotated as 1A–1I (described in the main text). Cell Systems 2017 4, 262-275DOI: (10.1016/j.cels.2017.02.010) Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 3 Engineering Strategies for Heterologous Expression of Biosynthetic Pathways in a Eukaryotic Host Cell Metabolites are denoted: S, Substrate; X1-6, pathway intermediates; P, product of interest; CS, co-substrate; E1-10, enzymes; FG, functional group. The inserted heterologous pathway is marked in green. Generic engineering strategies are boxed in blue and annotated as 2A–2F (described in the main text). Cell Systems 2017 4, 262-275DOI: (10.1016/j.cels.2017.02.010) Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 4 Overview of Generic Engineering Strategies for Expression of Proteins in a Eukaryotic Host Cell The inserted gene and its derived mRNA and polypeptide are marked in green. Generic engineering strategies are marked in blue and annotated as 3A–3J (described in the main text). Cell Systems 2017 4, 262-275DOI: (10.1016/j.cels.2017.02.010) Copyright © 2017 Elsevier Inc. Terms and Conditions