Transbronchial lung biopsy microscopic slide of a) lung tissue showing a granulomatous inflammation with giant cell reaction and b) lung tissue under polarised.

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Transbronchial lung biopsy microscopic slide of a) lung tissue showing a granulomatous inflammation with giant cell reaction and b) lung tissue under polarised light (birefringed crystalline material). c) Scanning transmission electron micrograph of the lun... Transbronchial lung biopsy microscopic slide of a) lung tissue showing a granulomatous inflammation with giant cell reaction and b) lung tissue under polarised light (birefringed crystalline material). c) Scanning transmission electron micrograph of the lung biopsy specimen showing sheets and fibres. In this area five different points were selected with the point and shoot utility. Points 1–4: electron dense crystalline material; point 5: control area. Scale bar = 100 nm. d) Energy-dispersive spectroscopy spectrum of point 1, all crystals in the lung biopsy specimen showed peaks for magnesium (Mg) and silicon (Si) in a ratio consistent with talc. Reference measurements such as point 5, however, showed only peaks for copper (Cu), originating from the copper carrier grid. A. van Huisstede et al. Eur Respir Rev 2010;19:165-168 ©2010 by European Respiratory Society